PMID- 7520991
OWN - NLM
STAT- MEDLINE
DCOM- 19940929
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 309
IP  - 2
DP  - 1994 Sep 1
TI  - Induction of micronuclei in peripheral blood and bone marrow erythrocytes of rats 
      and mice exposed to 1,3-butadiene by inhalation.
PG  - 315-20
AB  - Female CB6F1 mice and male Wistar rats were exposed to different concentrations 
      of 1,3-butadiene (1,3-BD) by inhalation. Micronucleus tests using both peripheral 
      blood erythrocytes and femoral marrow cells of these animals were performed. 
      Cells were stained either using conventional acridine orange (AO) staining or 
      supravitally using AO-coated slides. Dose-dependent increases in the frequency of 
      micronuclei (MN) were observed both in blood and in bone marrow cells in mice. 
      1,3-BD did not, however, increase the frequency of MN in either blood or bone 
      marrow cells of rats at any of the tested concentrations.
FAU - Autio, K
AU  - Autio K
AD  - Institute of Occupational Health, Laboratory of Molecular and Cellular 
      Toxicology, Helsinki, Finland.
FAU - Renzi, L
AU  - Renzi L
FAU - Catalan, J
AU  - Catalan J
FAU - Albrecht, O E
AU  - Albrecht OE
FAU - Sorsa, M
AU  - Sorsa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Butadienes)
RN  - 0 (Mutagens)
RN  - JSD5FGP5VD (1,3-butadiene)
SB  - IM
MH  - Administration, Inhalation
MH  - Animals
MH  - Bone Marrow/*pathology
MH  - Butadienes/administration & dosage/*toxicity
MH  - Dose-Response Relationship, Radiation
MH  - Erythrocytes/*drug effects/pathology
MH  - Female
MH  - Hematopoietic Stem Cells/drug effects/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Micronucleus Tests
MH  - Mutagens/*toxicity
MH  - Rats
MH  - Rats, Wistar
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 0027-5107(94)90108-2 [pii]
AID - 10.1016/0027-5107(94)90108-2 [doi]
PST - ppublish
SO  - Mutat Res. 1994 Sep 1;309(2):315-20. doi: 10.1016/0027-5107(94)90108-2.