PMID- 7521246
OWN - NLM
STAT- MEDLINE
DCOM- 19941004
LR  - 20190904
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 131
IP  - 2
DP  - 1994 Aug
TI  - No evidence for reduced spontaneous or growth-hormone-stimulated serum levels of 
      insulin-like growth factor (IGF)-I, IGF-II or IGF binding protein 3 in women with 
      spinal osteoporosis.
PG  - 150-5
AB  - To test the hypothesis that a dysfunctional growth hormone (GH)-insulin-like 
      growth factor (IGF) axis may play a role in the pathogenesis of osteoporosis, we 
      compared the levels of IGF-I, IGF-II and IGF binding protein 3 (IGFBP-3) in 15 
      women with spinal osteoporosis (i.e. at least one non-traumatic vertebral 
      fracture) and 15 normal age-matched women. Furthermore, the response to 3 days' 
      treatment with recombinant human GH (r-hGH) (0.2 IU kg-1.day-1) was determined. 
      The basal levels of IGF-I, IGF-II and IGFBP-3 were similar in patients and 
      controls (mean +/- SEM): IGF-I, 16.5 +/- 1.3 versus 16.0 +/- 1.3 nmol/l (NS); 
      IGF-II, 79.9 +/- 3.6 versus 72.5 +/- 4.1 nmol/l (NS); and IGFBP-3, 125.7 +/- 6.5 
      versus 130.3 +/- 7.8 nmol/l (NS). Stimulation with r-hGH elicited increased 
      levels of IGF-I, IGF-II and IGFBP-3 within both groups (p < 0.001). The maximal 
      values expressed as a percentage of baseline were: IGF-I, 341 +/- 26% versus 369 
      +/- 22%, IGF-II, 125 +/- 4% versus 119 +/- 5%, IGFBP-3, 141 +/- 5% versus 147 +/- 
      7% in osteoporotic patients and controls, respectively. No significant 
      differences were observed between patients and controls in either their maximal 
      response or in the area under the response curves. Our results do not support the 
      hypothesis of a dysfunctional GH-IGF axis in women with spinal osteoporosis.
FAU - Kassem, M
AU  - Kassem M
AD  - University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, 
      Denmark.
FAU - Brixen, K
AU  - Brixen K
FAU - Blum, W
AU  - Blum W
FAU - Mosekilde, L
AU  - Mosekilde L
FAU - Eriksen, E F
AU  - Eriksen EF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Carrier Proteins)
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Aged
MH  - Bone Density
MH  - Carrier Proteins/*metabolism
MH  - Female
MH  - Growth Hormone/*pharmacology
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Proteins
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Insulin-Like Growth Factor II/*metabolism
MH  - Middle Aged
MH  - Osteoporosis/*blood/metabolism
MH  - Spinal Diseases/*blood/metabolism
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 10.1530/eje.0.1310150 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 1994 Aug;131(2):150-5. doi: 10.1530/eje.0.1310150.