PMID- 75232
OWN - NLM
STAT- MEDLINE
DCOM- 19780426
LR  - 20211203
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 147
IP  - 1
DP  - 1978 Jan 1
TI  - A suppressor T cell of the mixed lymphocyte reaction in man specific for the 
      stimulating alloantigen. Evidence that identity at HLA-D between suppressor and 
      responder is required for suppression.
PG  - 137-46
AB  - It has previously been shown that J.H., a human leukocyte antigen (HLA)-Dw2 
      homozygous multiparous woman, fails to respond in a mixed lymphocyte reaction 
      (MLR) to her Dw1 homozygous husband W.H., and that her T cells suppress the 
      responses of HLA matched responders to W.H. The present studies take advantage of 
      the observation that J.H. suppressor cells resist a dose of gamma-irradiation 
      which functionally eliminates her MLR responder cells. J.H. cells, depleted of 
      alloreactive cells, suppress the responses of Dw2 heterozygous or homozygous 
      cells to W.H., regardless of their associated HLA-A or B antigens. Only when W.H. 
      or a few other cells are present as the irradiated stimulator is J.H. suppression 
      of Dw2 responses detected. Thus, the J.H. suppressor T cell recognizes 
      determinants in the irradiated stimulator cells as well as D locus products in 
      the responder.
FAU - Engleman, E G
AU  - Engleman EG
FAU - McMichael, A J
AU  - McMichael AJ
FAU - Batey, M E
AU  - Batey ME
FAU - McDevitt, H O
AU  - McDevitt HO
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Dose-Response Relationship, Radiation
MH  - Epitopes
MH  - Female
MH  - *HLA Antigens
MH  - Humans
MH  - *Immunosuppression Therapy
MH  - Lymphocyte Culture Test, Mixed
MH  - Male
MH  - Phenotype
MH  - Pregnancy
MH  - T-Lymphocytes/*immunology/radiation effects
PMC - PMC2184102
EDAT- 1978/01/01 00:00
MHDA- 1978/01/01 00:01
PMCR- 1978/07/01
CRDT- 1978/01/01 00:00
PHST- 1978/01/01 00:00 [pubmed]
PHST- 1978/01/01 00:01 [medline]
PHST- 1978/01/01 00:00 [entrez]
PHST- 1978/07/01 00:00 [pmc-release]
AID - 78110613 [pii]
AID - 10.1084/jem.147.1.137 [doi]
PST - ppublish
SO  - J Exp Med. 1978 Jan 1;147(1):137-46. doi: 10.1084/jem.147.1.137.