PMID- 7526306
OWN - NLM
STAT- MEDLINE
DCOM- 19941213
LR  - 20091026
IS  - 0029-7844 (Print)
IS  - 0029-7844 (Linking)
VI  - 84
IP  - 6
DP  - 1994 Dec
TI  - Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor 
      antagonist in plasma of women with preeclampsia: a mechanism for endothelial 
      dysfunction?
PG  - 937-40
AB  - OBJECTIVE: To determine if plasma concentrations of defined cytokines are 
      increased in women with preeclampsia, and to correlate any increases with the 
      elevated concentrations of the vascular cell adhesion molecule (VCAM)-1. METHODS: 
      Twenty primigravidas with preeclampsia were compared to 20 healthy primigravidas. 
      Plasma levels of cytokines, tumor necrosis factor-alpha (TNF alpha), interleukin 
      (IL)-6, IL-8, IL-1 beta, IL-1 receptor antagonist (IL-1ra), granulocyte 
      macrophage-colony-stimulating factor (GM-CSF), and VCAM-1, were measured by 
      enzyme-linked immunosorbent assay. RESULTS: Concentrations of IL-6 and IL-1ra 
      were significantly higher (P < .01) in preeclamptic women (2.56 and 251.85 pg/mL, 
      respectively) compared to normal pregnant patients (2.06 and 142.00 pg/mL, 
      respectively). There were no significant changes in concentrations of TNF alpha, 
      IL-8, GM-CSF, and IL-1 beta in preeclamptic patients (14.09, 50.52, 125.8, and 
      2.08 pg/mL, respectively) compared to normal patients (11.96 44.46, 121.3, and 
      2.01 pg/mL, respectively). Serum concentrations of VCAM-1 were increased in women 
      with preeclampsia (preeclamptic group 841.9 +/- 49.7 ng/mL, control group 560.2 
      +/- 47.9 ng/mL; t = 3.673, P < .001). Interleukin-6 and IL-1ra concentrations 
      correlated with VCAM-1 concentrations (IL-6: r = 0.539, z = 2.9, P < .005; 
      IL-1ra: r = 0.451, z = 2.428, P < .02). CONCLUSIONS: Increased cytokine 
      concentrations may contribute to the endothelial damage that occurs with 
      preeclampsia and may explain the mechanism underlying leukocyte activation in 
      this disorder. The increased cytokine concentration may also be responsible for 
      the endothelial adhesion that accompanies preeclampsia.
FAU - Greer, I A
AU  - Greer IA
AD  - Department of Obstetrics and Gynecology, Royal Infirmary, Glasgow, Scotland, 
      United Kingdom.
FAU - Lyall, F
AU  - Lyall F
FAU - Perera, T
AU  - Perera T
FAU - Boswell, F
AU  - Boswell F
FAU - Macara, L M
AU  - Macara LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Cell Adhesion Molecules/blood
MH  - Endothelium, Vascular/*physiopathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/blood
MH  - Humans
MH  - Interleukin-1/blood
MH  - Interleukin-6/*blood
MH  - Interleukin-8/blood
MH  - Pre-Eclampsia/*blood/physiopathology
MH  - Pregnancy
MH  - Receptors, Interleukin-1/*antagonists & inhibitors
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Vascular Cell Adhesion Molecule-1
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
PST - ppublish
SO  - Obstet Gynecol. 1994 Dec;84(6):937-40.