PMID- 7531972
OWN - NLM
STAT- MEDLINE
DCOM- 19950314
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 207
IP  - 1
DP  - 1995 Feb 6
TI  - RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis 
      and multiple endocrine neoplasia type 1-associated lipomas.
PG  - 363-8
AB  - Six lipomas from patients affected by Multiple Symmetric Lipomatosis (MSL) and by 
      Multiple Endocrine Neoplasia Type 1 (MEN 1) were analyzed for loss of 
      heterozygosity on chromosome 11 region q12-13 using four RFLPs. Allelic loss for 
      the D11S146 locus was found only in one visceral MEN 1-associated lipoma. Lipomas 
      that exhibited a lack of allelic lesions were analyzed for an eventual abnormal 
      amount or a defective function of the Gs protein by studying the Gs alpha subunit 
      gene, codons 201 and 207, by PCR and TGGE techniques. All the samples were 
      negative for activating mutations.
FAU - Morelli, A
AU  - Morelli A
AD  - Department of Clinical Physiopathology, University of Florence, Italy.
FAU - Falchetti, A
AU  - Falchetti A
FAU - Weinstein, L
AU  - Weinstein L
FAU - Fabiani, S
AU  - Fabiani S
FAU - Tomassetti, P
AU  - Tomassetti P
FAU - Enzi, G
AU  - Enzi G
FAU - Carraro, R
AU  - Carraro R
FAU - Bordi, C
AU  - Bordi C
FAU - Tonelli, F
AU  - Tonelli F
FAU - Brandi, M L
AU  - Brandi ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Codon)
RN  - 0 (DNA Primers)
RN  - 0 (Macromolecular Substances)
RN  - EC 3.1.21.- (Deoxyribonuclease HpaII)
RN  - EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
RN  - EC 3.1.21.4 (TCGA-specific type II deoxyribonucleases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
GS  - men 1
MH  - Alleles
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Codon
MH  - DNA Primers
MH  - Deoxyribonuclease HpaII
MH  - Deoxyribonucleases, Type II Site-Specific
MH  - GTP-Binding Proteins/genetics
MH  - Humans
MH  - Lipoma/*genetics
MH  - Lipomatosis, Multiple Symmetrical/*genetics
MH  - Macromolecular Substances
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Polymerase Chain Reaction/methods
MH  - *Polymorphism, Restriction Fragment Length
EDAT- 1995/02/06 00:00
MHDA- 1995/02/06 00:01
CRDT- 1995/02/06 00:00
PHST- 1995/02/06 00:00 [pubmed]
PHST- 1995/02/06 00:01 [medline]
PHST- 1995/02/06 00:00 [entrez]
AID - S0006291X85711965 [pii]
AID - 10.1006/bbrc.1995.1196 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1995 Feb 6;207(1):363-8. doi: 10.1006/bbrc.1995.1196.