PMID- 7533632
OWN - NLM
STAT- MEDLINE
DCOM- 19950412
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 665
IP  - 1
DP  - 1994 Nov 28
TI  - Tachykinin NK3 receptor agonist blocks sodium deficiency-induced shift in taste 
      reactivity.
PG  - 123-6
AB  - Intracerebroventricular (i.c.v.) injections of tachykinin NK3 receptor agonists 
      suppress NaCl intake by sodium deficient rats. The brief exposure, taste 
      reactivity test was used to examine the effect of tachykinins on the immediate, 
      oral reinforcing properties of NaCl (0.5 M) in sodium replete and sodium 
      deficient male rats. In sodium replete rats, intraoral infusions of NaCl elicited 
      a mixed response comprised of a similar number of ingestive and aversive 
      responses following i.c.v. injections of saline and 
      succinyl-[Asp6,N-Me-Phe8]substance P, (6-11), (SENK), a NK3 receptor agonist. 
      When sodium deficient, saline injected rats showed a reliable increase in 
      ingestive and a decrease in aversive taste reactivity responses. Lateral i.c.v. 
      injections of SENK blocked the shift in taste reactivity responses by sodium 
      deficient rats, indicating that concentrated NaCl retained its aversive taste 
      property.
FAU - Smith, M E
AU  - Smith ME
AD  - Department of Psychology, University of Wyoming, Laramie 82071.
FAU - Flynn, F W
AU  - Flynn FW
LA  - eng
GR  - NS24879/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Tachykinin)
RN  - 106128-89-6 (senktide)
RN  - 33507-63-0 (Substance P)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Animals
MH  - Evaluation Studies as Topic
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptide Fragments/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Tachykinin/*agonists
MH  - Sodium/*deficiency
MH  - Sodium Chloride/*pharmacology
MH  - Substance P/*analogs & derivatives/pharmacology
MH  - Taste/*drug effects
EDAT- 1994/11/28 00:00
MHDA- 1994/11/28 00:01
CRDT- 1994/11/28 00:00
PHST- 1994/11/28 00:00 [pubmed]
PHST- 1994/11/28 00:01 [medline]
PHST- 1994/11/28 00:00 [entrez]
AID - 0006-8993(94)91160-6 [pii]
AID - 10.1016/0006-8993(94)91160-6 [doi]
PST - ppublish
SO  - Brain Res. 1994 Nov 28;665(1):123-6. doi: 10.1016/0006-8993(94)91160-6.