PMID- 7533803
OWN - NLM
STAT- MEDLINE
DCOM- 19950410
LR  - 20190909
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 50
IP  - 2
DP  - 1994 Dec 15
TI  - Role of nitric oxide in regulation of baroreceptor reflex.
PG  - 209-19
AB  - The possible role of nitric oxide (NO) on modulating sympathetic nerve activity 
      through its action on baroreceptor reflex arc was investigated. L-Arginine, a 
      precursor of NO, and NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NO 
      synthase, were separately infused intravenously in increasing doses in 126 
      pentobarbital-anesthetized rabbits. Mean arterial pressure (MAP), heart rate 
      (HR), aortic nerve activity (ANA), cervical (CSNA) and renal sympathetic nerve 
      activities (RSNA) were recorded. L-Arginine infusion decreased MAP (P < 0.05), 
      ANA (P < 0.05), CSNA (P < 0.05) and RSNA (P < 0.05) without changes in HR. 
      Infusion of D-arginine, an enantiomer of L-arginine, and simultaneous infusion of 
      L-arginine and L-NMMA, did not elicit such changes. L-NMMA infusion increased MAP 
      (P < 0.05) and ANA (P < 0.05) and decreased HR (P < 0.05), while it tended to 
      increase CSNA and RSNA without significance. Infusion of L-arginine or L-NMMA did 
      not alter the slope of ANA, CSNA, RSNA, or HR in relation to MAP. These results 
      suggest that NO modulates efferent sympathetic nerve activity, not by altering 
      the afferent or efferent limbs of the baroreceptor reflex arc, but by interacting 
      with the sympathetic pathway in the central nervous system.
FAU - Jimbo, M
AU  - Jimbo M
AD  - Department of Internal Medicine, School of Medicine Keio University, Tokyo, 
      Japan.
FAU - Suzuki, H
AU  - Suzuki H
FAU - Ichikawa, M
AU  - Ichikawa M
FAU - Kumagai, K
AU  - Kumagai K
FAU - Nishizawa, M
AU  - Nishizawa M
FAU - Saruta, T
AU  - Saruta T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - 0 (Receptors, Presynaptic)
RN  - 27JT06E6GR (omega-N-Methylarginine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.4.- (Amino Acid Oxidoreductases)
RN  - G59M7S0WS3 (Nitroglycerin)
SB  - IM
MH  - Afferent Pathways/cytology/drug effects/physiology
MH  - Amino Acid Oxidoreductases/antagonists & inhibitors
MH  - Animals
MH  - Aorta/innervation/physiology
MH  - Arginine/analogs & derivatives/pharmacology
MH  - Baroreflex/drug effects/*physiology
MH  - Blood Pressure/drug effects/physiology
MH  - Female
MH  - Heart Rate/drug effects/physiology
MH  - Kidney/innervation/physiology
MH  - Nitric Oxide/antagonists & inhibitors/*physiology
MH  - Nitric Oxide Synthase
MH  - Nitroglycerin/pharmacology
MH  - Rabbits
MH  - Receptors, Presynaptic/drug effects/physiology
MH  - Sympathetic Nervous System/cytology/drug effects/physiology
MH  - omega-N-Methylarginine
EDAT- 1994/12/15 00:00
MHDA- 1994/12/15 00:01
CRDT- 1994/12/15 00:00
PHST- 1994/12/15 00:00 [pubmed]
PHST- 1994/12/15 00:01 [medline]
PHST- 1994/12/15 00:00 [entrez]
AID - 0165-1838(94)90011-6 [pii]
AID - 10.1016/0165-1838(94)90011-6 [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 1994 Dec 15;50(2):209-19. doi: 10.1016/0165-1838(94)90011-6.