PMID- 7533997
OWN - NLM
STAT- MEDLINE
DCOM- 19950413
LR  - 20061115
IS  - 0070-4113 (Print)
IS  - 0070-4113 (Linking)
VI  - 78
DP  - 1994
TI  - [Detection of human herpesvirus type 6, human herpesvirus type 7, cytomegalovirus 
      and human papillomavirus in cutaneous AIDS-associated Kaposi's sarcoma].
PG  - 260-4
AB  - In order to evaluate a possible role of viral infections in the pathogenesis of 
      AIDS-associated Kaposi's sarcoma (KS), we investigated 26 cutaneous 
      AIDS-associated KS by polymerase chain reaction (PCR), in situ hybridization, and 
      immunohistochemistry. By PCR we detected human papilloma viruses (HPV), 
      cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), and for the first time human 
      herpesvirus 7 (HHV-7) in the KS. The prevalence of HPV, HHV-6, and HHV-7 was 
      similar to or lower in KS than in normal skin tissues of AIDS patients without 
      KS, but higher than in normal skin of HIV-seronegative patients. All HHV-6 found 
      in KS were identified as HHV-6 variant B. In addition to the known HPV types 16 
      and 18 described in KS, we also found HPV types 6 and 33 in KS specimen. By 
      immunohistochemistry HHV-6 could be localized in macrophages in KS, in the 
      adjacent stroma as well as in normal skin of control cases. In situ hybridization 
      for CMV and HPV gave negative results in KS and controls.
FAU - Kempf, W
AU  - Kempf W
AD  - Departement Pathologie, Universitat Zurich.
FAU - Adams, V
AU  - Adams V
FAU - Hassam, S
AU  - Hassam S
FAU - Schmid, M
AU  - Schmid M
FAU - Moos, R
AU  - Moos R
FAU - Briner, J
AU  - Briner J
FAU - Pfaltz, M
AU  - Pfaltz M
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Nachweis von humanem Herpesvirus Typ 6, humanem Herpesvirus Typ 7, 
      Zytomegalievirus und humanen Papillomviren in kutanen AIDS-assoziierten 
      Kaposi-Sarkomen.
PL  - Germany
TA  - Verh Dtsch Ges Pathol
JT  - Verhandlungen der Deutschen Gesellschaft fur Pathologie
JID - 7503704
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*complications
MH  - Cytomegalovirus/*isolation & purification
MH  - HIV Seronegativity
MH  - HIV Seropositivity/pathology/virology
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Herpesvirus 7, Human/*isolation & purification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Macrophages/pathology/virology
MH  - Papillomaviridae/*isolation & purification
MH  - Polymerase Chain Reaction/methods
MH  - Reference Values
MH  - Sarcoma, Kaposi/etiology/*pathology/virology
MH  - Skin/cytology/pathology/*virology
MH  - Skin Neoplasms/etiology/*pathology/virology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Verh Dtsch Ges Pathol. 1994;78:260-4.