PMID- 7534176
OWN - NLM
STAT- MEDLINE
DCOM- 19950420
LR  - 20190904
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 132
IP  - 3
DP  - 1995 Mar
TI  - Growth hormone-binding protein-related immunoreactivity in the serum of patients 
      with acromegaly is regulated inversely by growth hormone concentration.
PG  - 306-12
AB  - In this report we describe a newly developed radioimmunoassay (RIA) for the 
      determination of the high-affinity growth hormone-binding protein (GHBP) in human 
      blood. Using this RIA for the measurement of GHBP in serum of 29 patients with 
      acromegaly, decreased concentrations were found compared to the normal range, 
      depending on the activity of the disease. Growth hormone-binding protein was 
      correlated inversely to log GH (r = -0.7, p < 0.001). A weaker relationship was 
      shown between the GHBP activity determined in a functional assay based on 
      charcoal separation and log GH (r = -0.51, p < 0.01). While insulin-like growth 
      factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) were correlated directly to 
      log GH (r = 0.77 and r = 0.66, p < 0.001), an inverse and weaker relationship was 
      evident between GHBP measured by RIA and IGF-I or IGFBP-3 (r = -0.61 and r = 
      -0.57, p < 0.01). In contrast, no correlation could be detected between data of 
      the functional GHBP assay and IGF-I or IGFBP-3.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Kratzsch, J
AU  - Kratzsch J
AD  - Department of Clinical Chemistry, University of Leipzig, Germany.
FAU - Blum, W F
AU  - Blum WF
FAU - Ventz, M
AU  - Ventz M
FAU - Selisko, T
AU  - Selisko T
FAU - Birkenmeyer, G
AU  - Birkenmeyer G
FAU - Keller, E
AU  - Keller E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Carrier Proteins)
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
RN  - W06KFL3RDT (somatotropin-binding protein)
SB  - IM
MH  - Acromegaly/*blood
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Carrier Proteins/*blood
MH  - Female
MH  - Growth Hormone/*blood
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Proteins
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Male
MH  - Middle Aged
MH  - Radioimmunoassay
MH  - Reference Values
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
AID - 10.1530/eje.0.1320306 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 1995 Mar;132(3):306-12. doi: 10.1530/eje.0.1320306.