PMID- 7534949
OWN - NLM
STAT- MEDLINE
DCOM- 19950426
LR  - 20041117
IS  - 0171-6425 (Print)
IS  - 0171-6425 (Linking)
VI  - 42
IP  - 6
DP  - 1994 Dec
TI  - Aortic valve replacement for end-stage aortic valve disease.
PG  - 321-4
AB  - To evaluate the outcome of surgical intervention for end-stage aortic valve 
      disease, we carried out a retrospective, longitudinal survey of 85 patients (65 
      males, 20 females; mean age 53 period. All the patients presented in New York 
      Heart Association (NYHA) class IV in cardiac failure (3 had cardiogenic shock and 
      27 had bacterial endocarditis). In-hospital mortality was 9.4% (8/85) overall. 
      Those with endocarditis had a significantly higher mortality, 6/27 (22%) vs 2/58 
      (3.4%), p < 0.01. In-hospital mortality was not significantly increased in those 
      with renal failure, reoperation, simultaneous coronary artery surgery, age > 65 
      years nor was it related to the predominance of aortic regurgitation or stenosis. 
      After a mean follow-up period of 5.9 years (range 0 to 12.5 years), the overall 
      actuarial survival was 82% and 74% at 5 and 10 years respectively. For 66 late 
      survivors, the NYHA status improved to class I in 51, to II in 10, to III in 4 
      patients, and one patient remained in class IV. The incidence of paraprosthetic 
      leak, reoperation, thromboembolism, anticoagulant-related haemorrhage, and 
      endocarditis were respectively 0.8, 0.8, 1.6, 1.4, and 0.2 per 100 patient-years. 
      Aortic valve replacement in the patient with end-stage aortic valve disease is a 
      high-risk procedure, the risk being higher in the presence of endocarditis. The 
      favourable long-term survival, long-term improvement in functional class and the 
      relatively low incidence of valve-related complications justify surgical 
      intervention in such patients, who would otherwise have a very poor prognosis.
FAU - Kadri, M A
AU  - Kadri MA
AD  - Regional Cardiothoracic Surgery Department, Wythenshawe Hospital, Manchester, 
      U.K.
FAU - Levy, R D
AU  - Levy RD
FAU - Nashef, S A
AU  - Nashef SA
FAU - Jones, M T
AU  - Jones MT
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Thorac Cardiovasc Surg
JT  - The Thoracic and cardiovascular surgeon
JID - 7903387
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aortic Valve
MH  - Chi-Square Distribution
MH  - Confidence Intervals
MH  - England/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Valve Diseases/mortality/surgery
MH  - *Heart Valve Prosthesis/mortality/statistics & numerical data
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.1055/s-2007-1016514 [doi]
PST - ppublish
SO  - Thorac Cardiovasc Surg. 1994 Dec;42(6):321-4. doi: 10.1055/s-2007-1016514.