PMID- 7535652
OWN - NLM
STAT- MEDLINE
DCOM- 19950510
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 668
IP  - 1-2
DP  - 1994 Dec 30
TI  - Further localization of cardiovascular and behavioral actions of substance P in 
      the rat brain.
PG  - 100-6
AB  - Cardiovascular and behavioral actions of substance P (SP) were examined after 
      microinjection into the medial preoptic area (MPO), anterior hypothalamic area 
      (AH), and ventral tegmental area (VTA) in conscious unrestrained rats. SP 
      elicited marked increases in mean arterial pressure and heart rate as well as 
      stereotyped behaviors of excessive grooming and exploring when injected into the 
      MPO or AH. In the MPO, the latencies to the cardiovascular responses were 
      observed after SP injection into the VTA. These results, together with our 
      previous results, suggest that SP acts as transmitter or modulator in the rostral 
      hypothalamic areas to elicit cardiovascular defense responses. In contrast, SP 
      may not be involved in causing a defense reaction in the more caudal areas of the 
      defense center.
FAU - Itoi, K
AU  - Itoi K
AD  - Department of Pharmacology, University of Heidelberg, Germany.
FAU - Jost, N
AU  - Jost N
FAU - Culman, J
AU  - Culman J
FAU - Tschope, C
AU  - Tschope C
FAU - Unger, T
AU  - Unger T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Blood Pressure
MH  - Drug Administration Routes
MH  - Heart Rate
MH  - Hypothalamus, Anterior/drug effects/*physiology
MH  - Male
MH  - Microinjections
MH  - Rats
MH  - Rats, Wistar
MH  - Substance P/administration & dosage/*pharmacology/physiology
MH  - Ventral Tegmental Area/drug effects/*physiology
EDAT- 1994/12/30 00:00
MHDA- 1994/12/30 00:01
CRDT- 1994/12/30 00:00
PHST- 1994/12/30 00:00 [pubmed]
PHST- 1994/12/30 00:01 [medline]
PHST- 1994/12/30 00:00 [entrez]
AID - 0006-8993(94)90515-0 [pii]
AID - 10.1016/0006-8993(94)90515-0 [doi]
PST - ppublish
SO  - Brain Res. 1994 Dec 30;668(1-2):100-6. doi: 10.1016/0006-8993(94)90515-0.