PMID- 7535998
OWN - NLM
STAT- MEDLINE
DCOM- 19950511
LR  - 20200304
IS  - 0304-8608 (Print)
IS  - 0304-8608 (Linking)
VI  - 140
IP  - 2
DP  - 1995
TI  - Immune recognition of genetically diverse simian T-cell lymphotropic virus type I 
      isolates.
PG  - 307-23
AB  - Nucleotide sequence analysis of selected regions of the gag, pol, env and pX 
      genes of simian T-cell lymphotropic virus type I (STLV-I) strains indicated that 
      African isolates were more closely related to human T-cell lymphotropic virus 
      type I (HTLV-I) than Asian isolates. Despite these recent comparative studies on 
      nucleotide sequence homology between HTLV-I and STLV-I isolates, only limited 
      information is available regarding the influence of genetic differences on 
      antigen-antibody recognition of distinct STLV-I strains. In this study, we 
      demonstrated that sera from STLV-I-infected yellow baboons (Papio cynocephalus) 
      reacted strongly with env gp62/68 from HTLV-I-infected cell lines MT-2 and 
      C10/MJ. In contrast, sera from Japanese macaques (Macaca fuscata) naturally 
      infected with Asian STLV-I had weak reactivity to env gp62/68 of these prototypic 
      HTLV-I strains. Pst-1 restriction enzyme analysis of proviral DNA indicated that 
      the baboon virus isolates were more closely related to HTLV-I than the Japanese 
      isolates. These results indicate that nucleotide sequence diversity, correlates 
      with variations in proviral restriction enzyme sites and antibody recognition of 
      viral envelope proteins. These differences in immunoreactivity may have important 
      implications for serologic diagnosis, as well as epidemiological and vaccine 
      studies of STLV-I infection.
FAU - Lazo, A
AU  - Lazo A
AD  - Department of Veterinary Anatomy and Cellular Biology, Ohio State University, 
      Columbus, USA.
FAU - Bailer, R T
AU  - Bailer RT
FAU - Blakeslee, J R
AU  - Blakeslee JR
FAU - Yanagihara, R
AU  - Yanagihara R
FAU - Stevens, V C
AU  - Stevens VC
FAU - Kramer, L
AU  - Kramer L
FAU - Lairmore, M D
AU  - Lairmore MD
LA  - eng
GR  - P30 CA16058/CA/NCI NIH HHS/United States
GR  - R29 CA55185/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Epitopes)
RN  - 0 (Viral Envelope Proteins)
RN  - EC 3.1.21.4 (CTGCAG-specific type II deoxyribonucleases)
RN  - EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood/*immunology
MH  - *Antigenic Variation
MH  - Antigens, Viral/genetics/*immunology
MH  - Cell Line
MH  - Cross Reactions
MH  - DNA, Viral/genetics
MH  - Deltaretrovirus Infections/immunology/virology
MH  - Deoxyribonucleases, Type II Site-Specific
MH  - Epitopes/immunology
MH  - Genes, Viral
MH  - Macaca
MH  - Papio
MH  - Proviruses/genetics
MH  - Radioimmunoprecipitation Assay
MH  - Simian T-lymphotropic virus 1/genetics/*immunology
MH  - T-Lymphocytes/virology
MH  - Viral Envelope Proteins/genetics/*immunology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1007/BF01309864 [doi]
PST - ppublish
SO  - Arch Virol. 1995;140(2):307-23. doi: 10.1007/BF01309864.