PMID- 7536463
OWN - NLM
STAT- MEDLINE
DCOM- 19950523
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 12
IP  - 3
DP  - 1995 Mar
TI  - Defining the position of the breakpoint of the constitutional t(3;6) occurring in 
      a family with renal cell carcinoma.
PG  - 224-8
AB  - In a family with a constitutional translocation t(3;6), the oldest member 
      carrying the translocation had developed multiple nonpapillary renal cell 
      carcinomas (RCCs). The translocation breakpoint was positioned between 3p13 and 
      3p14.1. This is close to the region in which a t(3;8) breakpoint has been 
      reported in a family with hereditary RCC. We defined the location of the t(3;6) 
      and t(3;8) breakpoints by fluorescence in situ hybridization (FISH) analysis with 
      yeast artificial chromosomes (YACs) from the 3p14-13 region. Both interphase 
      nuclei and metaphase cells from translocation-carrying members of both families 
      have been used, allowing the definition of flanking YACs for each breakpoint. We 
      could thereby clearly confirm that the breakpoints are different, the t(3;8) 
      breakpoint being most distal. In addition, we have shown that both translocation 
      breakpoints are located distal to the homozygously deleted region in the U2020 
      lung cancer cell line.
FAU - van den Berg, A
AU  - van den Berg A
AD  - Department of Medical Genetics, University of Groningen, The Netherlands.
FAU - van der Veen, A Y
AU  - van der Veen AY
FAU - Hulsbeek, M M
AU  - Hulsbeek MM
FAU - Kovacs, G
AU  - Kovacs G
FAU - Gemmill, R M
AU  - Gemmill RM
FAU - Drabkin, H A
AU  - Drabkin HA
FAU - Buys, C H
AU  - Buys CH
LA  - eng
GR  - 2R01 HG00358/HG/NHGRI NIH HHS/United States
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Carcinoma, Renal Cell/*genetics
MH  - Cells, Cultured
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - *Chromosomes, Human, Pair 3
MH  - *Chromosomes, Human, Pair 6
MH  - Chromosomes, Human, Pair 8
MH  - Fibroblasts
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics
MH  - *Translocation, Genetic
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
AID - 10.1002/gcc.2870120311 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 Mar;12(3):224-8. doi: 10.1002/gcc.2870120311.