PMID- 7537456
OWN - NLM
STAT- MEDLINE
DCOM- 19950601
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 268
IP  - 4 Pt 1
DP  - 1995 Apr
TI  - Regulation and localization of the insulin-like growth factor system in small 
      bowel during altered nutrient status.
PG  - G631-40
AB  - Insulin-like growth factor-I (IGF-I) may regulate small bowel growth. Analyses 
      here in ad libitum-fed, fasted, and refed rats demonstrate that during fasting 
      and refeeding changes in jejunal mass correlate with changes in serum IGF-I and 
      jejunal IGF-I mRNAs. These data indicate that circulating and locally expressed 
      IGF-I contribute to nutrient regulation of jejunal mass. During refeeding, 
      jejunal IGF binding protein 3 (IGFBP-3) mRNA abundance was reduced relative to 
      that of IGF-I, possibly amplifying enterotrophic actions of IGF-I. Localization 
      of IGFBP-3 to subepithelial cells in lamina propria of jejunum indicates that 
      IGFBP-3 derived from lamina propria may modulate IGF-I action on adjacent 
      epithelium. Ileum differed from jejunum in that refeeding did not increase bowel 
      mass or IGF-I mRNA to ad libitum values. Differences in exposure to luminal 
      nutrient may underlie distinct responses of the two segments. Rats fed elemental 
      diet intravenously showed reduced jejunal mass but not reduced jejunal IGF-I mRNA 
      compared with rats fed oral elemental diet. Elemental nutrient given 
      intravenously or orally therefore does not differ in effects on jejunal IGF-I 
      expression. Complex luminal nutrient may, however, regulate jejunal IGF-I 
      expression.
FAU - Winesett, D E
AU  - Winesett DE
AD  - Department of Pediatrics, Chapel Hill 27599-7545, USA.
FAU - Ulshen, M H
AU  - Ulshen MH
FAU - Hoyt, E C
AU  - Hoyt EC
FAU - Mohapatra, N K
AU  - Mohapatra NK
FAU - Fuller, C R
AU  - Fuller CR
FAU - Lund, P K
AU  - Lund PK
LA  - eng
GR  - DK-01022/DK/NIDDK NIH HHS/United States
GR  - DK-34987/DK/NIDDK NIH HHS/United States
GR  - DK-40247/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Carrier Proteins)
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Somatomedin)
RN  - 0 (Receptors, Somatotropin)
RN  - 0 (Somatomedins)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animal Feed
MH  - *Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Carrier Proteins/genetics
MH  - Fasting
MH  - Insulin-Like Growth Factor Binding Proteins
MH  - Insulin-Like Growth Factor I/analysis/genetics
MH  - Intestine, Small/*metabolism
MH  - Jejunum/metabolism
MH  - Male
MH  - Parenteral Nutrition, Total
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Somatomedin/genetics
MH  - Receptors, Somatotropin/genetics
MH  - Somatomedins/*metabolism
MH  - Tissue Distribution
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1152/ajpgi.1995.268.4.G631 [doi]
PST - ppublish
SO  - Am J Physiol. 1995 Apr;268(4 Pt 1):G631-40. doi: 10.1152/ajpgi.1995.268.4.G631.