PMID- 7537613
OWN - NLM
STAT- MEDLINE
DCOM- 19950608
LR  - 20191031
IS  - 1096-4940 (Print)
IS  - 1096-4940 (Linking)
VI  - 111
IP  - 1
DP  - 1995 May
TI  - Effects of the epileptogenic agent strychnine on membrane currents elicited by 
      agonists of the NMDA and non-NMDA receptors in Xenopus oocytes.
PG  - 65-71
AB  - The effects of strychnine (STRY) on ion channels activated by 
      N-methyl-D-aspartate (NMDA), kainate (KA), 
      alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA) and quisqualate (QUIS) 
      were studied using Xenopus oocytes, microinjected with mRNA from rats' brains. 
      STRY reduced NMDA-, KA- and AMPA-induced membrane currents in a dose-dependent 
      manner. The effect was more pronounced with NMDA than with KA and AMPA. 
      QUIS-induced membrane currents were not affected by STRY. The depressive effect 
      of STRY on NMDA responses was voltage dependent. The effect of STRY on the 
      NMDA-induced membrane currents remains unchanged when the concentration of NMDA 
      or glycine was increased. Intracellular injection of STRY did not alter the NMDA 
      response.
FAU - Musshoff, U
AU  - Musshoff U
AD  - Institut fur Physiologie, Munster, Germany.
FAU - Madeja, M
AU  - Madeja M
FAU - Bloms-Funke, P
AU  - Bloms-Funke P
FAU - Speckmann, E J
AU  - Speckmann EJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Comp Biochem Physiol A Physiol
JT  - Comparative biochemistry and physiology. Part A, Physiology
JID - 9516062
RN  - 0 (Ion Channels)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Kainic Acid)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 77521-29-0 (alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - H9Y79VD43J (Strychnine)
RN  - SIV03811UC (Kainic Acid)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Electrophysiology
MH  - Glycine/pharmacology
MH  - Ion Channels/*drug effects
MH  - Kainic Acid/pharmacology
MH  - N-Methylaspartate/pharmacology
MH  - Oocytes/*chemistry/*ultrastructure
MH  - Quisqualic Acid/pharmacology
MH  - RNA, Messenger/administration & dosage
MH  - Rats
MH  - Receptors, AMPA/*agonists
MH  - Receptors, Kainic Acid/*agonists
MH  - Receptors, N-Methyl-D-Aspartate/*agonists
MH  - Strychnine/*pharmacology
MH  - Xenopus laevis
MH  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1016/0300-9629(95)98521-h [doi]
PST - ppublish
SO  - Comp Biochem Physiol A Physiol. 1995 May;111(1):65-71. doi: 
      10.1016/0300-9629(95)98521-h.