PMID- 7539287
OWN - NLM
STAT- MEDLINE
DCOM- 19950706
LR  - 20220129
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 12
IP  - 4
DP  - 1995 Apr
TI  - Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid 
      chondrosarcoma.
PG  - 307-10
AB  - Southern blot analyses revealed a rearrangement of the EWS gene in a skeletal 
      human myxoid chondrosarcoma. Interphase fluorescence in situ hybridization (FISH) 
      studies, using cosmid clones F7 and G9 that flank the EWS locus on 22q12, 
      confirmed the presence of this EWS gene abnormality. Cloning the rearranged EWS 
      DNA fragment and mapping by FISH demonstrated that the EWS gene is joined to DNA 
      sequences localised in 9q22-31. These findings are consistent with previous 
      cytogenetic reports of a recurrent t(9;22)(q22-31;q11-12) in the myxoid variant 
      of chondrosarcoma and reveal involvement of the EWS gene in a fourth type of 
      human sarcoma.
FAU - Gill, S
AU  - Gill S
AD  - Section of Molecular Carcinogenesis, Haddow Laboratories, Sutton, Surrey, United 
      Kingdom.
FAU - McManus, A P
AU  - McManus AP
FAU - Crew, A J
AU  - Crew AJ
FAU - Benjamin, H
AU  - Benjamin H
FAU - Sheer, D
AU  - Sheer D
FAU - Gusterson, B A
AU  - Gusterson BA
FAU - Pinkerton, C R
AU  - Pinkerton CR
FAU - Patel, K
AU  - Patel K
FAU - Cooper, C S
AU  - Cooper CS
FAU - Shipley, J M
AU  - Shipley JM
LA  - eng
GR  - A3585/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Heterogeneous-Nuclear Ribonucleoproteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Ribonucleoproteins)
SB  - IM
GS  - EWS
MH  - Adult
MH  - Aged
MH  - Chondrosarcoma/*genetics/pathology
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 22
MH  - *Chromosomes, Human, Pair 9
MH  - Cloning, Molecular
MH  - DNA, Neoplasm/metabolism
MH  - Female
MH  - Heterogeneous-Nuclear Ribonucleoproteins
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/genetics
MH  - Nuclear Proteins/*genetics
MH  - RNA-Binding Protein EWS
MH  - RNA-Binding Proteins/*genetics
MH  - Restriction Mapping
MH  - Ribonucleoproteins/*genetics
MH  - *Translocation, Genetic
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1002/gcc.2870120412 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 Apr;12(4):307-10. doi: 10.1002/gcc.2870120412.