PMID- 7539551
OWN - NLM
STAT- MEDLINE
DCOM- 19950705
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 268
IP  - 5216
DP  - 1995 Jun 9
TI  - Identification of a graft versus host disease-associated human minor 
      histocompatibility antigen.
PG  - 1476-80
AB  - Minor histocompatibility antigen disparities between human leukocyte antigen 
      (HLA)-matched bone marrow donors and recipients are a major risk factor for graft 
      versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that 
      recognized the minor histocompatibility antigen HA-2 was previously isolated from 
      a patient with severe GVHD after HLA-identical bone marrow transplantation. The 
      HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide 
      appears to originate from a member of the non-filament-forming class I myosin 
      family. Because HA-2 has a phenotype frequency of 95 percent in the 
      HLA-A2.1-positive population, it is a candidate for immunotherapeutic 
      intervention in bone marrow transplantation.
FAU - den Haan, J M
AU  - den Haan JM
AD  - Department of Immunohaematology, University Hospital, Leiden, Netherlands.
FAU - Sherman, N E
AU  - Sherman NE
FAU - Blokland, E
AU  - Blokland E
FAU - Huczko, E
AU  - Huczko E
FAU - Koning, F
AU  - Koning F
FAU - Drijfhout, J W
AU  - Drijfhout JW
FAU - Skipper, J
AU  - Skipper J
FAU - Shabanowitz, J
AU  - Shabanowitz J
FAU - Hunt, D F
AU  - Hunt DF
FAU - Engelhard, V H
AU  - Engelhard VH
AU  - et al.
LA  - eng
GR  - AI20963/AI/NIAID NIH HHS/United States
GR  - AI33993/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Epitopes)
RN  - 0 (HA-2 antigen)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oligopeptides)
SB  - IM
MH  - Amino Acid Sequence
MH  - Bone Marrow Transplantation
MH  - Epitopes
MH  - Female
MH  - Graft vs Host Disease/*immunology
MH  - HLA-A2 Antigen/immunology
MH  - Humans
MH  - Mass Spectrometry
MH  - Minor Histocompatibility Antigens/chemistry/*immunology
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/chemistry/*immunology
MH  - Oligopeptides/chemistry/immunology
MH  - T-Lymphocytes, Cytotoxic/immunology
EDAT- 1995/06/09 00:00
MHDA- 1995/06/09 00:01
CRDT- 1995/06/09 00:00
PHST- 1995/06/09 00:00 [pubmed]
PHST- 1995/06/09 00:01 [medline]
PHST- 1995/06/09 00:00 [entrez]
AID - 10.1126/science.7539551 [doi]
PST - ppublish
SO  - Science. 1995 Jun 9;268(5216):1476-80. doi: 10.1126/science.7539551.