PMID- 7540603
OWN - NLM
STAT- MEDLINE
DCOM- 19950727
LR  - 20190920
IS  - 0017-8470 (Print)
IS  - 0017-8470 (Linking)
VI  - 46
IP  - 4
DP  - 1995 Apr
TI  - [Autoimmune-associated MHC class II molecules].
PG  - 225-7
AB  - The major histocompatibility complex (MHC) is a large region of highly 
      polymorphic genes. MHC-encoded molecules bind foreign-protein antigens and form 
      complexes that are recognized by antigen-specific T lymphocytes. Interactions 
      between MHC-peptide complexes and T-cell receptors play a central role in the 
      selection of the T-cell repertoire and in the elicitation of an immune response. 
      The majority of disease associations with the MHC have been with class-II 
      molecules. Despite the awareness of such associations, the pathophysiological 
      role of MHC class-II molecules in conferring susceptibility to autoimmune disease 
      is poorly understood. The recent demonstration that human class-II molecules can 
      function as antigen-presenting molecules in vivo in a transgenic murine system 
      paves the way to investigate the role of HLA class II molecules in regulating 
      immune responses and disease susceptibility. These mice should be useful for 
      studying the mechanisms by which particular human leukocyte antigen (HLA) alleles 
      are associated with specific human-autoimmune diseases.
FAU - Trueb, M
AU  - Trueb M
AD  - University of Texas Southwestern Medical Center at Dallas 75235-9069, USA.
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Autoaggressionskrankheit-assoziierte MHC-Klasse-II-Molekule.
PL  - Germany
TA  - Hautarzt
JT  - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
JID - 0372755
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Autoimmune Diseases/*genetics/immunology
MH  - Epitopes/immunology
MH  - Genes, Dominant
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Major Histocompatibility Complex/*genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Receptors, Antigen, T-Cell/genetics/immunology
MH  - T-Lymphocytes/immunology
RF  - 21
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1007/s001050050244 [doi]
PST - ppublish
SO  - Hautarzt. 1995 Apr;46(4):225-7. doi: 10.1007/s001050050244.