PMID- 7540941
OWN - NLM
STAT- MEDLINE
DCOM- 19950802
LR  - 20220409
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 2
IP  - 6
DP  - 1995 Jun
TI  - Tumor necrosis factor-alpha is required in the protective immune response against 
      Mycobacterium tuberculosis in mice.
PG  - 561-72
AB  - Understanding the immunological mechanisms of protection and pathogenesis in 
      tuberculosis remains problematic. We have examined the extent to which tumor 
      necrosis factor-alpha (TNF alpha) contributes to this disease using murine models 
      in which the action of TNF alpha is inhibited. TNF alpha was neutralized in vivo 
      by monoclonal antibody; in addition, a mouse strain with a disruption in the gene 
      for the 55 kDa TNF receptor was used. The data from both models established that 
      TNF alpha and the 55 kDa TNF receptor are essential for protection against 
      tuberculosis in mice, and for reactive nitrogen production by macrophages early 
      in infection. Granulomas were formed in equal numbers in control and experimental 
      mice, but necrosis was observed only in mice deficient in TNF alpha or TNF 
      receptor. TNF alpha and the 55 kDa TNF receptor are necessary conditions for 
      protection against murine M. tuberculosis infection, but are not solely 
      responsible for the tissue damage observed.
FAU - Flynn, J L
AU  - Flynn JL
AD  - Department of Molecular Genetics and Biochemistry, University of Pittsburgh 
      School of Medicine, Pennsylvania 15261, USA.
FAU - Goldstein, M M
AU  - Goldstein MM
FAU - Chan, J
AU  - Chan J
FAU - Triebold, K J
AU  - Triebold KJ
FAU - Pfeffer, K
AU  - Pfeffer K
FAU - Lowenstein, C J
AU  - Lowenstein CJ
FAU - Schreiber, R
AU  - Schreiber R
FAU - Mak, T W
AU  - Mak TW
FAU - Bloom, B R
AU  - Bloom BR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (BCG Vaccine)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.4.- (Amino Acid Oxidoreductases)
SB  - IM
MH  - Amino Acid Oxidoreductases/biosynthesis
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - BCG Vaccine/immunology
MH  - Female
MH  - Granuloma/etiology
MH  - Immunization
MH  - Immunohistochemistry
MH  - Lung/enzymology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mycobacterium tuberculosis/*immunology
MH  - Nitric Oxide Synthase
MH  - Polymerase Chain Reaction
MH  - Receptors, Tumor Necrosis Factor/genetics/immunology
MH  - Tuberculosis/*prevention & control
MH  - Tumor Necrosis Factor-alpha/*immunology
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 1074-7613(95)90001-2 [pii]
AID - 10.1016/1074-7613(95)90001-2 [doi]
PST - ppublish
SO  - Immunity. 1995 Jun;2(6):561-72. doi: 10.1016/1074-7613(95)90001-2.