PMID- 7541645
OWN - NLM
STAT- MEDLINE
DCOM- 19950811
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 13
IP  - 1
DP  - 1995 May
TI  - Involvement of chromosomes 17 and 22 in dermatofibrosarcoma protuberans.
PG  - 62-5
AB  - Literature on the cytogenetics of dermatofibrosarcoma protuberans (DFSP) is 
      limited; only 10 cases with chromosome aberrations have been reported. They are 
      karyotypically characterized by the presence of supernumerary ring(s), either as 
      the sole cytogenetic abnormality or together with a few additional structural or 
      numerical changes. We report the cytogenetic and fluorescence in situ 
      hybridization (FISH) analysis of three new DFSP, one primary and two recurrent 
      tumors. In two cases we found a supernumerary ring as the sole change, whereas 
      the third had two copies of a marker chromosome and monosomy of chromosome 22. 
      Sequences of chromosomes 17 and 22 were identified by FISH in the supernumerary 
      rings and in the markers. The fluorescence pattern suggested that additional 
      sequences were present in the two rings, but showed that the marker chromosomes 
      were entirely painted by chromosome 17 and 22 probes. The findings indicate that 
      juxtaposition and/or amplification of chromosome 17 and 22 sequences could be 
      crucial in the pathogenesis of DFSP.
FAU - Minoletti, F
AU  - Minoletti F
AD  - Division of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy.
FAU - Miozzo, M
AU  - Miozzo M
FAU - Pedeutour, F
AU  - Pedeutour F
FAU - Sard, L
AU  - Sard L
FAU - Pilotti, S
AU  - Pilotti S
FAU - Azzarelli, A
AU  - Azzarelli A
FAU - Turc-Carel, C
AU  - Turc-Carel C
FAU - Pierotti, M A
AU  - Pierotti MA
FAU - Sozzi, G
AU  - Sozzi G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Adult
MH  - Aneuploidy
MH  - *Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 22
MH  - Dermatofibrosarcoma/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Ring Chromosomes
MH  - Skin Neoplasms/*genetics
RF  - 21
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1002/gcc.2870130110 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 May;13(1):62-5. doi: 10.1002/gcc.2870130110.