PMID- 7541648
OWN - NLM
STAT- MEDLINE
DCOM- 19950811
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 13
IP  - 1
DP  - 1995 May
TI  - Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.
PG  - 9-17
AB  - Two molecular defects have been described in parathyroid adenomas: rearrangement 
      and overexpression of the PRAD1/cyclin D1 oncogene and allelic loss of chromosome 
      11 DNA, often including the multiple endocrine neoplasia type 1 (MEN1) putative 
      tumor suppressor gene region. In an effort to identify additional parathyroid 
      tumor suppressor genes, we examined 25 parathyroid adenomas for tumor-specific 
      allelic loss of polymorphic DNA loci located near known or candidate tumor 
      suppressor genes. Control leukocyte DNA from all 25 patients was heterozygous for 
      1 or more of the 9 chromosome 1 markers examined. Allelic loss at 1 or more of 
      these informative loci on chromosome 1 was observed in 10 of 25 (40%) adenomas. 
      Although many tumors lost extensive regions on chromosome 1, all but one of these 
      tumors had allelic loss of distal 1p (1p32-pter); four tumors also lost loci on 
      1q. Allelic loss at 11q13, the site of the MEN1 gene, was detected in 5 of 21 
      (24%) informative cases, including 3 with 1p loss. In contrast, allelic loss was 
      rarely observed at loci on 9q and 10p and was not observed at loci on 3p, 3q, 4p, 
      5q, 12q, 14q, 18q, 22q, or Xp. In summary, clonal allelic loss of loci on 
      chromosome arm 1p is a frequent feature of parathyroid adenomas, implying that 
      inactivation of a tumor suppressor gene(s) on 1p commonly contributes to their 
      pathogenesis.
FAU - Cryns, V L
AU  - Cryns VL
AD  - Laboratory of Endocrine Oncology, Massachusetts General Hospital, Boston 02114, 
      USA.
FAU - Yi, S M
AU  - Yi SM
FAU - Tahara, H
AU  - Tahara H
FAU - Gaz, R D
AU  - Gaz RD
FAU - Arnold, A
AU  - Arnold A
LA  - eng
GR  - 1F32CA-0938101/CA/NCI NIH HHS/United States
GR  - 1K08CA-0172-01A1/CA/NCI NIH HHS/United States
GR  - DK-11794/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Cyclins)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Genetic Markers)
RN  - 0 (Oncogene Proteins)
RN  - 136601-57-5 (Cyclin D1)
RN  - 9007-49-2 (DNA)
SB  - IM
GS  - APC
GS  - DCC
GS  - MEN1
GS  - MYCL1
MH  - Adenoma/*genetics
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - *Chromosomes, Human, Pair 1
MH  - Cyclin D1
MH  - Cyclins/biosynthesis/genetics
MH  - DNA/analysis
MH  - DNA, Neoplasm/analysis
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Deletion
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Rearrangement
MH  - Genetic Markers
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins/biosynthesis/genetics
MH  - Parathyroid Neoplasms/*genetics
MH  - Transcriptional Activation
RF  - 64
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1002/gcc.2870130103 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103.