PMID- 7542214
OWN - NLM
STAT- MEDLINE
DCOM- 19950824
LR  - 20220409
IS  - 0892-6638 (Print)
IS  - 0892-6638 (Linking)
VI  - 9
IP  - 10
DP  - 1995 Jul
TI  - Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and 
      cytokine-inducible enhancers.
PG  - 899-909
AB  - Transcription of endothelial-leukocyte adhesion molecule-1 (E-selectin or 
      ELAM-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion 
      molecule-1 (ICAM-1) is induced by the inflammatory cytokines interleukin-1 beta 
      (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha). The positive regulatory 
      domains required for maximal levels of cytokine induction have been defined in 
      the promoters of all three genes. DNA binding studies reveal a requirement for 
      nuclear factor-kappa B (NF-kappa B) and a small group of other transcriptional 
      activators. The organization of the cytokine-inducible element in the E-selectin 
      promoter is remarkably similar to that of the virus-inducible promoter of the 
      human interferon-beta gene in that both promoters require NF-kappa B, activating 
      transcription factor-2 (ATF-2), and high mobility group protein I(Y) for 
      induction. Based on this structural similarity, a model has been proposed for the 
      cytokine-induced E-selectin enhancer that is similar to the stereospecific 
      complex proposed for the interferon-beta gene promoter. In these models, multiple 
      DNA bending proteins facilitate the assembly of higher order complexes of 
      transcriptional activators that interact as a unit with the basal transcriptional 
      machinery. The assembly of unique enhancer complexes from similar sets of 
      transcriptional factors may provide the specificity required to regulate complex 
      patterns of gene expression and correlate with the distinct patterns of 
      expression of the leukocyte adhesion molecules.
FAU - Collins, T
AU  - Collins T
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 
      USA.
FAU - Read, M A
AU  - Read MA
FAU - Neish, A S
AU  - Neish AS
FAU - Whitley, M Z
AU  - Whitley MZ
FAU - Thanos, D
AU  - Thanos D
FAU - Maniatis, T
AU  - Maniatis T
LA  - eng
GR  - A12064/PHS HHS/United States
GR  - HL03011-01/HL/NHLBI NIH HHS/United States
GR  - HL45462/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (E-Selectin)
RN  - 0 (NF-kappa B)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Base Sequence
MH  - Cell Adhesion Molecules/*genetics
MH  - Cytokines/*pharmacology
MH  - DNA/metabolism
MH  - E-Selectin
MH  - Endothelium, Vascular/metabolism
MH  - Enhancer Elements, Genetic
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*genetics
MH  - Molecular Sequence Data
MH  - NF-kappa B/*pharmacology
MH  - Transcription, Genetic
MH  - Vascular Cell Adhesion Molecule-1
RF  - 72
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
PST - ppublish
SO  - FASEB J. 1995 Jul;9(10):899-909.