PMID- 7542803
OWN - NLM
STAT- MEDLINE
DCOM- 19950831
LR  - 20220316
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 269
IP  - 5224
DP  - 1995 Aug 4
TI  - Molecular identification of an IgE-dependent histamine-releasing factor.
PG  - 688-90
AB  - An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by 
      lymphocytes of atopic children and present in biological fluids of allergic 
      patients has been identified and purified. Amino-terminal sequencing revealed 
      extensive homology to a mouse protein, p21, and its human homolog, p23. Both 
      recombinant proteins caused histamine release from the human basophils of a 
      subpopulation of donors, and this release was dependent on IgE. Polyclonal 
      antibodies recognized and removed the biological activity of recombinant and 
      native HRF. HRF identifies a heterogeneity of IgE and is believed to play a 
      prominent role in chronic allergic disease processes.
FAU - MacDonald, S M
AU  - MacDonald SM
AD  - Department of Medicine, Johns Hopkins University School of Medicine, Johns 
      Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.
FAU - Rafnar, T
AU  - Rafnar T
FAU - Langdon, J
AU  - Langdon J
FAU - Lichtenstein, L M
AU  - Lichtenstein LM
LA  - eng
GR  - AI 07290/AI/NIAID NIH HHS/United States
GR  - AI 32651/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antibodies)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Lymphokines)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Tumor Protein, Translationally-Controlled 1)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies/immunology
MH  - Base Sequence
MH  - Basophils/immunology
MH  - *Biomarkers, Tumor
MH  - Cell Line
MH  - Cloning, Molecular
MH  - *Histamine Release
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Kinetics
MH  - Lymphokines/*chemistry/immunology/isolation & purification/pharmacology
MH  - Macrophages/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Recombinant Fusion Proteins/pharmacology
MH  - Sequence Homology, Amino Acid
MH  - Tumor Protein, Translationally-Controlled 1
EDAT- 1995/08/04 00:00
MHDA- 1995/08/04 00:01
CRDT- 1995/08/04 00:00
PHST- 1995/08/04 00:00 [pubmed]
PHST- 1995/08/04 00:01 [medline]
PHST- 1995/08/04 00:00 [entrez]
AID - 10.1126/science.7542803 [doi]
PST - ppublish
SO  - Science. 1995 Aug 4;269(5224):688-90. doi: 10.1126/science.7542803.