PMID- 7542908
OWN - NLM
STAT- MEDLINE
DCOM- 19950906
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 13
IP  - 2
DP  - 1995 Jun
TI  - BCR/ABL fusion located on chromosome 9 in chronic myeloid leukemia with a masked 
      Ph chromosome.
PG  - 133-7
AB  - A reciprocal translocation, t(10;22)(q22;q11), resulting in a masked Ph 
      chromosome was identified in a patient diagnosed with chronic myeloid leukemia 
      (CML). Both homologs of chromosome 9 were of the normal pattern. Two signals for 
      the ABL probe, both of them hybridized to chromosome 9, were demonstrated via 
      fluorescence in situ hybridization (FISH). Furthermore, cohybridization with two 
      differently labeled BCR/ABL translocation DNA probes indicated a BCR/ABL fusion 
      apparently located on 9q34. Molecular studies revealed a rearrangement of the BCR 
      region and expression of a chimeric BCR/ABL mRNA of CML configuration. These 
      findings indicate that the BCR/ABL fusion resulted from an unusual relocation of 
      the BCR gene from its normal position on 22q11 to 9q34 adjacent to the ABL gene.
FAU - Mohamed, A N
AU  - Mohamed AN
AD  - Department of Pathology, Harper Hospital, Wayne State University, Detroit, 
      Michigan 48201, USA.
FAU - Koppitch, F
AU  - Koppitch F
FAU - Varterasian, M
AU  - Varterasian M
FAU - Karanes, C
AU  - Karanes C
FAU - Yao, K L
AU  - Yao KL
FAU - Sarkar, F H
AU  - Sarkar FH
LA  - eng
GR  - 5-P30 CA-22453/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - *Chromosomes, Human, Pair 9
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - *Genes, abl
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Philadelphia Chromosome
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 10.1002/gcc.2870130210 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 Jun;13(2):133-7. doi: 10.1002/gcc.2870130210.