PMID- 7542909
OWN - NLM
STAT- MEDLINE
DCOM- 19950906
LR  - 20220129
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 13
IP  - 2
DP  - 1995 Jun
TI  - Characterization of a t(10;11)(p13-14;q14-21) in the monoblastic cell line U937.
PG  - 138-42
AB  - Previous analysis of the monoblastic cell line U937 has shown that several 
      sublines contain a rearranged chromosome arm 11q. In order to determine the true 
      nature of the rearrangement, fluorescence in situ hybridization (FISH) was 
      carried out with various combinations of single copy anonymous markers, clones 
      containing genes, a chromosome 10 paint, and an 11 centromere specific sequence. 
      The rearrangement was deduced to be a reciprocal translocation between 
      chromosomes 10 and 11 described as t(10;11)(p13-14;q14-21). The breakpoint on 
      chromosome 11 is telomeric to the INT2 gene and the pHS11 probe at 11q13, and 
      centromeric to the marker D11S36 localized to 11q14.3-q22.1 and the MLL gene at 
      11q23. Similar translocations have been reported in various acute leukemias, 
      principally of the monocytic lineage, and also in T-cell precursor acute 
      lymphocytic leukemias. Further characterization of the genetic rearrangements in 
      U937 may lead to the isolation of genes important in leukemogenesis and provide 
      an in vitro system for their study.
FAU - Shipley, J
AU  - Shipley J
AD  - Institute of Cancer Research, Sutton, Surrey, United Kingdom.
FAU - Williams, S
AU  - Williams S
FAU - O'Byrne, A
AU  - O'Byrne A
FAU - Kearney, L
AU  - Kearney L
FAU - Jones, T
AU  - Jones T
FAU - Young, B
AU  - Young B
FAU - Dyer, M
AU  - Dyer M
FAU - Catovsky, D
AU  - Catovsky D
FAU - Sheer, D
AU  - Sheer D
FAU - Gusterson, B
AU  - Gusterson B
LA  - eng
GR  - A3585/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 10
MH  - *Chromosomes, Human, Pair 11
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics
MH  - *Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 10.1002/gcc.2870130211 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 Jun;13(2):138-42. doi: 10.1002/gcc.2870130211.