PMID- 7542913
OWN - NLM
STAT- MEDLINE
DCOM- 19950906
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 13
IP  - 2
DP  - 1995 Jun
TI  - Childhood acute lymphoblastic leukemia with equivocal chromosome markers of the 
      t(1;19) translocation.
PG  - 99-103
AB  - The t(1;19)(q23;p13) or its derivative encodes an E2A-PBXI fusion transcript and 
      protein that has been shown to have important prognostic and therapeutic 
      implications in patients with acute lymphoblastic leukemia (ALL). We describe two 
      childhood cases in which a der(22)t(1;22)(q21-23;p13) cytogenetically mimicked a 
      der(19)t(1;19)(q23;p13). In one case, which was phenotyped as early pre-B ALL 
      with hyperdiploidy but lacked evidence of an E2A-PBX1 gene fusion by molecular 
      study, the poor banding quality of chromosomes led to misinterpretation of the 
      cytogenetic findings; a correct diagnosis was established only after analysis by 
      the fluorescence in situ hybridization (FISH) method. The second case, which was 
      classified as pseudodiploid pre-B ALL, had both a derivative 19 and a derivative 
      22 but lacked sufficient cells for evaluation of E2A-PBX1 gene fusion. This case 
      was included in order to compare the der(19)t(1;19) and the der(22)t(1;22) and to 
      pinpoint the difficulty in distinguishing these markers. FISH analysis can 
      resolve diagnostic uncertainty in cases of ALL with equivocal chromosome 19 
      markers.
FAU - Filatov, L V
AU  - Filatov LV
AD  - Department of Pathology and Laboratory Medicine, St. Jude Children's Research 
      Hospital, Memphis, Tennessee 38105, USA.
FAU - Behm, F G
AU  - Behm FG
FAU - Pui, C H
AU  - Pui CH
FAU - Head, D R
AU  - Head DR
FAU - Downing, J R
AU  - Downing JR
FAU - Raimondi, S C
AU  - Raimondi SC
LA  - eng
GR  - CA 20180/CA/NCI NIH HHS/United States
GR  - CA 21765/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 19
MH  - Female
MH  - Genetic Markers/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 10.1002/gcc.2870130205 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1995 Jun;13(2):99-103. doi: 10.1002/gcc.2870130205.