PMID- 7544277
OWN - NLM
STAT- MEDLINE
DCOM- 19950922
LR  - 20131121
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 136
IP  - 9
DP  - 1995 Sep
TI  - Somatostatin may participate in the antiinflammatory actions of glucocorticoids.
PG  - 4133-8
AB  - Glucocorticoids are potent antiinflammatory agents. They inhibit leukocyte 
      chemotaxis and vascular permeability and generally suppress the expression of 
      many inflammatory mediators. Recent reports suggested that somatostatin (Sms) had 
      significant immunomodulatory properties in vitro and in vivo. In this study we 
      examined the effects of glucocorticoids on immunoreactive somatostatin expression 
      in aseptic inflammatory sites of Sprague-Dawley rats given carrageenin sc. The 
      progress of the inflammatory reaction was studied over a 7-h period with respect 
      to the volume and cellularity of the exudate and the levels of the inflammatory 
      mediators expressed in the inflammatory site, including immunoreactive substance 
      P (sP), corticotropin-releasing hormone (CRH), and tumor necrosis factor-alpha 
      (TNF alpha). Dexamethasone significantly reduced the volume and cellularity of 
      the inflammatory exudates; in parallel, the levels of immunoreactive sP, CRH, and 
      TNF alpha were significantly suppressed by this glucocorticoid. In contrast, 
      immunoreactive Sms was stimulated by dexamethasone in a time-dependent fashion. 
      These findings suggest another mechanism for suppression of the inflammatory 
      reaction by glucocorticoids via stimulation of local Sms expression, which occurs 
      in parallel to the inhibition of the local inflammatory mediators sP, CRH, and 
      TNF alpha.
FAU - Karalis, K
AU  - Karalis K
AD  - Developmental Endocrinology Branch, National Institutes of Child Health and 
      Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Mastorakos, G
AU  - Mastorakos G
FAU - Sano, H
AU  - Sano H
FAU - Wilder, R L
AU  - Wilder RL
FAU - Chrousos, G P
AU  - Chrousos GP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Glucocorticoids)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 33507-63-0 (Substance P)
RN  - 51110-01-1 (Somatostatin)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9000-07-1 (Carrageenan)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Carrageenan/toxicity
MH  - Corticotropin-Releasing Hormone/analysis/metabolism/physiology
MH  - Dexamethasone/pharmacology
MH  - Endothelium/chemistry/pathology
MH  - Fibroblasts/chemistry/pathology
MH  - Glucocorticoids/*therapeutic use
MH  - Granuloma/chemically induced/drug therapy/pathology
MH  - Immunohistochemistry
MH  - Leukocytes/chemistry/pathology
MH  - Macrophages/chemistry/pathology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/chemistry/metabolism/pathology
MH  - Skin Diseases/chemically induced/drug therapy/pathology
MH  - Somatostatin/analysis/metabolism/*physiology
MH  - Substance P/analysis/metabolism/physiology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/analysis/metabolism/physiology
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1210/endo.136.9.7544277 [doi]
PST - ppublish
SO  - Endocrinology. 1995 Sep;136(9):4133-8. doi: 10.1210/endo.136.9.7544277.