PMID- 7545708
OWN - NLM
STAT- MEDLINE
DCOM- 19951017
LR  - 20190825
IS  - 0385-2407 (Print)
IS  - 0385-2407 (Linking)
VI  - 22
IP  - 5
DP  - 1995 May
TI  - Clinical and histopathologic analysis of the relationship between lichen planus 
      and chronic hepatitis C.
PG  - 316-23
AB  - A prospective clinical investigation of 45 patients with lichen planus (LP) 
      demonstrated a significant association between LP and chronic hepatitis C. 
      Anti-hepatitis C virus (HCV) antibodies were found in 17 (37.8%) of the 45 LP 
      patients. This was significantly higher than in the controls. This higher 
      prevalence of anti-HCV antibodies was found equally in both male and female 
      patients in the three types of LP; cutaneous only type, mucous only type, and 
      both cutaneous and mucous type. Most of the patients with positive anti-HCV 
      antibodies had abnormal values of transaminase enzymes and/or a past history of 
      chronic hepatitis. Histological and immunohistological investigations of three 
      cases with LP and chronic hepatitis C demonstrated some morphologic similarities 
      between these two diseases. Histopathologic findings of both LP and chronic 
      hepatitis C were based on a T lymphocytic infiltrate with keratinocyte or 
      hepatocyte damage. The degrees of infiltrating cells positive to UCHL-1, MX-panB, 
      Leu-7, and human leukocyte antigen (HLA)-DR antibodies in the chronic hepatitis C 
      lesions seemed to be similar to those in the LP lesions. These results may 
      support a possible relationship between LP and chronic hepatitis C and the 
      hypothesis that LP may be associated with chronic liver diseases as a result of a 
      cytotoxic attack on the hepatocytes.
FAU - Tanei, R
AU  - Tanei R
AD  - Department of Dermatology, School of Medicine, Kitasato University, Kanagawa, 
      Japan.
FAU - Watanabe, K
AU  - Watanabe K
FAU - Nishiyama, S
AU  - Nishiyama S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (Hepatitis Antibodies)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Hepatitis C Antibodies)
RN  - EC 2.6.1.- (Transaminases)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Female
MH  - Hepacivirus/immunology
MH  - Hepatitis Antibodies/*analysis
MH  - Hepatitis B Surface Antigens/analysis
MH  - Hepatitis C/*complications/enzymology/immunology/pathology
MH  - Hepatitis C Antibodies
MH  - Hepatitis, Chronic/*complications/enzymology/immunology/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Lichen Planus/*complications/enzymology/immunology/pathology
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Transaminases/analysis
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1111/j.1346-8138.1995.tb03395.x [doi]
PST - ppublish
SO  - J Dermatol. 1995 May;22(5):316-23. doi: 10.1111/j.1346-8138.1995.tb03395.x.