PMID- 7546273
OWN - NLM
STAT- MEDLINE
DCOM- 19951121
LR  - 20221207
IS  - 1015-2008 (Print)
IS  - 1015-2008 (Linking)
VI  - 63
IP  - 1
DP  - 1995
TI  - Progression of HIV infection is associated with HLA-DQ antigens in Caucasians and 
      African Americans.
PG  - 22-41
AB  - In our previous work with human leukocyte antigen (HLA) association in human 
      immunodeficiency virus (HIV) infection, African Americans (Afr Ams) and 
      Caucasians (Caucs) exhibited HLA markers that were associated with protection or 
      disease. The present study was designed to establish if HLAs were associated with 
      the severity of HIV infection and progression to AIDS in Afr Am and Cauc adults. 
      The frequency of serologically determined antigens (Ags) in the regional control 
      population was compared to the HIV-infected population and the HIV-infected slow 
      progressors were compared to rapid progressors by race. chi 2 analysis with 
      Bonferroni adjustment, Kaplan-Meier survival analysis, linear logistic 
      regression, Cox model of proportional hazards and standardized deltas were 
      applied as applicable. Immune parameters were monitored over a mean follow-up 
      period of 23 +/- 2 months for Afr Ams (n = 35) and 25 +/- 5 months for Caucs (n = 
      24). A better prognosis in the HIV+Afr Am group was associated with HLA-DQ1 with 
      a risk ratio of 0.295. In the HIV+Cauc group, a preferable prognosis was 
      associated with HLA-DQ3 with a risk ratio of 0.11, and a poor prognosis was 
      associated with HLA-DQ2 with a risk ratio of 7. Afr Am haplotypes that appeared 
      to have the greatest association with rapid progression of HIV infection were 
      A69(28)-B40 and related haplotypes as well as B12-DR14(6). Cauc haplotypes with 
      the strongest association with rapid and slow progression of HIV infection were 
      A28-B17-DR9 and A30(19)-B67, respectively. The DR Ags of at least one haplotype 
      that led to rapid progression in both races were associated with DQ9(3). An 
      'immune response' gene (DQ region) may control the progression of HIV infection 
      in adults. The rapidly progressive DQ-associated peptide might block the 
      progression of HIV if given as a novel vaccine.
FAU - Brackin, M N
AU  - Brackin MN
AD  - Department of Pathology, University of Mississippi Medical Center, Jackson 39216, 
      USA.
FAU - Lewis, R E
AU  - Lewis RE
FAU - Brackin, B T
AU  - Brackin BT
FAU - Achord, A
AU  - Achord A
FAU - Henderson, H
AU  - Henderson H
FAU - Crawford, M
AU  - Crawford M
FAU - Cruse, J M
AU  - Cruse JM
LA  - eng
GR  - 2S07RR05386/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Pathobiology
JT  - Pathobiology : journal of immunopathology, molecular and cellular biology
JID - 9007504
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Black People/*genetics
MH  - Blotting, Western
MH  - Disease Progression
MH  - Female
MH  - HIV Infections/*immunology/mortality/physiopathology
MH  - HLA-DQ Antigens/genetics/*physiology
MH  - Haplotypes
MH  - Humans
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - T-Lymphocytes/immunology/pathology
MH  - United States/epidemiology
MH  - White People/*genetics
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1159/000163931 [doi]
PST - ppublish
SO  - Pathobiology. 1995;63(1):22-41. doi: 10.1159/000163931.