PMID- 7547431
OWN - NLM
STAT- MEDLINE
DCOM- 19951107
LR  - 20181113
IS  - 0959-9673 (Print)
IS  - 1365-2613 (Electronic)
IS  - 0959-9673 (Linking)
VI  - 76
IP  - 3
DP  - 1995 Jun
TI  - Detection of herpesvirus DNA in cottontop tamarins: no association with colitis.
PG  - 201-3
AB  - Colitis occurs spontaneously in the cottontop tamarin; it shares similar 
      clinical, endoscopic and histological features with, and has a similar response 
      to treatment as, human ulcerative colitis. An association between human 
      ulcerative colitis and the presence of DNA from multiple herpesviruses (human 
      herpesvirus 6 (HHV-6), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in the 
      colon has been described. Intestinal herpesvirus infection may be involved in the 
      pathogenesis of this condition. In a pilot study, coded full thickness colonic 
      specimens from 27 cottontop tamarins were examined for the presence of HHV-6, CMV 
      and EBV DNA using the nested polymerase chain reaction. The sections represented 
      a spectrum of disease activity ranging from histologically normal bowel to severe 
      colitis. A low prevalence of DNA from these viruses was found, which bore no 
      relation to the presence of inflammation. Although these herpesviruses may have a 
      pathogenetic role in human ulcerative colitis, they are not associated with 
      colitis in this animal model.
FAU - Smith, M S
AU  - Smith MS
AD  - Inflammatory Bowel Disease Study Group, Royal Free Hospital School of Medicine, 
      London, UK.
FAU - Warren, B F
AU  - Warren BF
FAU - Fox, J D
AU  - Fox JD
FAU - Watkins, P E
AU  - Watkins PE
FAU - Hudson, M
AU  - Hudson M
FAU - Pounder, R E
AU  - Pounder RE
FAU - Wakefield, A J
AU  - Wakefield AJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Exp Pathol
JT  - International journal of experimental pathology
JID - 9014042
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Colitis, Ulcerative/*veterinary/virology
MH  - Cytomegalovirus/isolation & purification
MH  - DNA, Viral/*analysis
MH  - Herpesviridae/*isolation & purification
MH  - Herpesvirus 4, Human/isolation & purification
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Monkey Diseases/*virology
MH  - Polymerase Chain Reaction
MH  - *Saguinus
PMC - PMC1997171
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
PMCR- 1995/06/01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
PHST- 1995/06/01 00:00 [pmc-release]
PST - ppublish
SO  - Int J Exp Pathol. 1995 Jun;76(3):201-3.