PMID- 7547822
OWN - NLM
STAT- MEDLINE
DCOM- 19951026
LR  - 20190719
IS  - 0007-1145 (Print)
IS  - 0007-1145 (Linking)
VI  - 74
IP  - 1
DP  - 1995 Jul
TI  - Influences of dietary and intraduodenal lipid on alertness, mood, and sustained 
      concentration.
PG  - 115-23
AB  - The effects of intraduodenal and dietary lipid on alertness, mood and performance 
      in a task requiring sustained attention were investigated in two studies. The 
      first experiment compared the effect of duodenal infusion of either 100 g/l 
      Intralipid (8.36 kJ/min) or isotonic saline (9 g NaCl/l) in paired studies 
      carried out on two non-consecutive days on five male volunteers. Two consecutive 
      3 h infusions, one of lipid, the other saline, were given blind on each day using 
      a crossover design. Analysis of variance indicated that lipid significantly 
      reduced alertness (P < 0.05) and affected the speed and accuracy of performance 
      in a sustained attention task (P < 0.05). A second experiment compared the 
      effects on eight male volunteers of two isoenergetic lunches of similar 
      appearance, taste and protein content but differing fat and carbohydrate (CHO) 
      contents (fat energy:CHO, 64:18 v. 7:76). Alertness was lower (P < 0.05) and 
      responses to stimuli in a sustained attention task were slower after the high-fat 
      meal than after the low-fat meal (P < 0.05). In conclusion, infusion of lipid 
      into the small intestine, and the substitution of fat for carbohydrate while 
      keeping energy and protein constant in a lunch, both cause an enhanced 
      postprandial decline in alertness and concentration. This may be related to the 
      presence of lipid in the small intestine.
FAU - Wells, A S
AU  - Wells AS
AD  - Centre for Human Nutrition, University of Sheffield, Northern General Hospital.
FAU - Read, N W
AU  - Read NW
FAU - Craig, A
AU  - Craig A
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Adult
MH  - Affect/*drug effects
MH  - Attention/*drug effects
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Duodenum/*metabolism
MH  - *Eating
MH  - Humans
MH  - Male
MH  - *Task Performance and Analysis
MH  - Time Factors
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - S0007114595001127 [pii]
AID - 10.1079/bjn19950111 [doi]
PST - ppublish
SO  - Br J Nutr. 1995 Jul;74(1):115-23. doi: 10.1079/bjn19950111.