PMID- 7548618
OWN - NLM
STAT- MEDLINE
DCOM- 19951121
LR  - 20220321
IS  - 1045-4411 (Print)
IS  - 1045-4411 (Linking)
VI  - 6
IP  - 2
DP  - 1995
TI  - Chemokines, a family of chemotactic cytokines.
PG  - 109-18
AB  - Chemokines are low-molecular-weight proteins that stimulate recruitment of 
      leukocytes. They are secondary pro-inflammatory mediators that are induced by 
      primary pro-inflammatory mediators such as interleukin-1 (IL-1) or tumor necrosis 
      factor (TNF). The physiologic importance of this family of mediators is derived 
      from their specificity. Unlike the classic leukocyte chemo-attractants, which 
      have little specificity, members of the chemokine family induce recruitment of 
      well-defined leukocyte subsets. Thus, chemokine expression can account for the 
      presence of different types of leukocytes observed in various normal or 
      pathologic states. There are two major chemokine sub-families based upon the 
      position of cysteine residues, i.e., CXC and CC. All members of the CXC chemokine 
      sub-family have an intervening amino acid between the first two cysteines; 
      members of the CC chemokine sub-family have two adjacent cysteines. As a general 
      rule (with some notable exceptions), members of the CXC chemokines are 
      chemotactic for neutrophils, and CC chemokines are chemotactic for monocytes and 
      a small sub-set of lymphocytes. This review discusses the potential role of 
      chemokines in inflammation and focuses on the two best-characterized chemokines, 
      monocyte chemoattractant protein-1 (MCP-1), a CC chemokine, and interleukin-8 
      (IL-8), a member of the CXC chemokine sub-family.
FAU - Graves, D T
AU  - Graves DT
AD  - Department of Periodontology and Oral Biology, Boston University School of 
      Graduate Dentistry, Massachusetts 02118, USA.
FAU - Jiang, Y
AU  - Jiang Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Crit Rev Oral Biol Med
JT  - Critical reviews in oral biology and medicine : an official publication of the 
      American Association of Oral Biologists
JID - 9009999
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Chemokine CCL2/physiology
MH  - Chemokines/classification/genetics/*physiology
MH  - Chemotaxis, Leukocyte
MH  - Cysteine
MH  - Gene Expression
MH  - Humans
MH  - Inflammation Mediators/physiology
MH  - Interleukin-1/physiology
MH  - Interleukin-8/physiology
MH  - Leukocytes/physiology
MH  - Lymphocyte Subsets/physiology
MH  - Monocytes/physiology
MH  - Neutrophils/physiology
MH  - Tumor Necrosis Factor-alpha/physiology
RF  - 106
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1177/10454411950060020101 [doi]
PST - ppublish
SO  - Crit Rev Oral Biol Med. 1995;6(2):109-18. doi: 10.1177/10454411950060020101.