PMID- 7549446
OWN - NLM
STAT- MEDLINE
DCOM- 19951107
LR  - 20221007
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 5
IP  - 2
DP  - 1995 Apr-Jun
TI  - Ocular pathology in light chain deposition disease.
PG  - 75-81
AB  - Light-chain deposition disease (LCDD), a rare form of monoclonal gammopathy, is 
      characterized by deposits of amorphous light-chain material, mainly in the 
      kidneys but also in various other organs. Here we present the first report of a 
      light-, electron microscopic and immunohistochemical study of the globes of a 
      patient suffering from LCDD secondary to multiple myeloma. Massive deposits of 
      kappa light chains similar to those typically present in the kidneys were found 
      beneath the basement membrane of the ciliary pigment epithelium, on vessels of 
      the ciliary body, within the collagenous zones of Bruch's membrane, and in the 
      innermost part of the choroid. The choriocapillaris in the macular area was 
      partly obstructed by these deposits, and an exudative retinal detachment was 
      present. Whether this detachment was the consequence of disturbed circulation of 
      the choriocapillaris remains speculative.
FAU - Daicker, B C
AU  - Daicker BC
AD  - University Eye Hospital Basel, Switzerland.
FAU - Mihatsch, M J
AU  - Mihatsch MJ
FAU - Strom, E H
AU  - Strom EH
FAU - Fogazzi, G B
AU  - Fogazzi GB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Immunoglobulin kappa-Chains)
SB  - IM
MH  - Adult
MH  - Basement Membrane/metabolism/pathology
MH  - Blood Vessels/pathology
MH  - Bruch Membrane/metabolism/pathology
MH  - Choroid/blood supply/metabolism/pathology
MH  - Ciliary Body/blood supply/metabolism/pathology
MH  - Eye Diseases/*etiology/metabolism/*pathology
MH  - Fatal Outcome
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Hypergammaglobulinemia/*etiology/metabolism/*pathology
MH  - Immunoglobulin kappa-Chains/*metabolism
MH  - Multiple Myeloma/complications
MH  - Pigment Epithelium of Eye/metabolism/pathology
MH  - Retinal Detachment/etiology/pathology
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1177/112067219500500202 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 1995 Apr-Jun;5(2):75-81. doi: 10.1177/112067219500500202.