PMID- 7549461
OWN - NLM
STAT- MEDLINE
DCOM- 19951122
LR  - 20131121
IS  - 0924-977X (Print)
IS  - 0924-977X (Linking)
VI  - 5
IP  - 2
DP  - 1995 Jun
TI  - Effects of 6-hydroxydopamine lesions of the medial prefrontal cortex on local 
      cerebral blood flow and D1 and D2 dopamine receptor binding in rats: a 
      quantitative autoradiographic study.
PG  - 95-101
AB  - The effects of lesions of the dopamine (DA) nerve terminals in the medial 
      prefrontal cortex (MPFC) on local cerebral blood flow (LCBF) and DA receptor 
      binding in rats were investigated. 4 micrograms of 6-hydroxydopamine (6-OHDA) was 
      infused stereotaxically into the area of the bilateral MPFC of rats pretreated 
      with desmethylimipramine, and control rats received a vehicle solution. 
      Twenty-four days after the operation LCBFs of 23 brain regions were measured 
      using the quantitative autoradiographic N-isopropyl-p-[125I]iodoamphetamine 
      technique D1 and D2 DA receptor binding in various brain regions was also 
      quantified autoradiographically using [3H]SCH 23390 and [3H]YM 09151-2 as the 
      respective ligands. 6-OHDA lesions of MPFC produced significant increases in LCBF 
      of the nucleus accumbens, the dorsolateral portion of the caudate-putamen and the 
      anterior cingulate cortex. The lesioned animals did not show decreased LCBF in 
      MPFC per se. D1 and D2 DA receptor binding was not affected in any brain region 
      examined. These results suggest that lesions of the DA nerve terminals in MPFC 
      induce an enhancement of functional activity in the terminal regions of the 
      subcortical DA systems, and that hypofunction of the mesocortical dopamine system 
      does not elicit reduced metabolic activity in the prefrontal cortex.
FAU - Suzuki, M
AU  - Suzuki M
AD  - Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and 
      Pharmaceutical University, Japan.
FAU - Kawasaki, Y
AU  - Kawasaki Y
FAU - Murata, M
AU  - Murata M
FAU - Shibata, R
AU  - Shibata R
FAU - Kurachi, M
AU  - Kurachi M
FAU - Mori, H
AU  - Mori H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 8HW4YBZ748 (Oxidopamine)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Cerebrovascular Circulation/*drug effects
MH  - Frontal Lobe/*metabolism
MH  - Male
MH  - Oxidopamine/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Dopamine D1/*drug effects
MH  - Receptors, Dopamine D2/*drug effects
MH  - Regional Blood Flow/*drug effects
MH  - Schizophrenia
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 0924-977X(95)00003-8 [pii]
AID - 10.1016/0924-977X(95)00003-8 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 1995 Jun;5(2):95-101. doi: 
      10.1016/0924-977X(95)00003-8.