PMID- 7550013
OWN - NLM
STAT- MEDLINE
DCOM- 19951106
LR  - 20161018
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 27
IP  - 12
DP  - 1994 Dec
TI  - Injection of ramipril into the lateral ventricle interferes with the drinking 
      response induced by pharmacological and natural thirst stimuli.
PG  - 2909-13
AB  - We investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) 
      inhibitor, on water intake by male Holtzman rats (250-300 g) with cannulae 
      implanted into the lateral ventricle. Intracerebroventricular (i.c.v.) injection 
      of ramipril (1 microgram/microliter) significantly reduced drinking in response 
      to subcutaneous (s.c.) injection of isoprenaline (100 micrograms/kg) from 8.49 
      +/- 0.69 to 2.96 +/- 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) 
      from 9.51 +/- 2.20 to 1.6 +/- 0.34 ml/2 h or water deprivation for 24 h from 
      12.61 +/- 0.83 to 5.10 +/- 1.37 ml/2 h. Ramipril had no effect on water intake 
      induced by cellular dehydration produced by sc injection of hypertonic saline (2 
      M NaCI). These results are consistent with the hypothesis that ramipril acts as 
      an ACE-blocking agent in the brain. The possibility that ramipril is transformed 
      to ramiprilat, the active drug, by the brain is suggested.
FAU - Saad, W A
AU  - Saad WA
AD  - Departamento de Ciencias Fisiologicas, Faculdade de Odontologia, Universidade 
      Estadual Paulista, Araraquara, Brasil.
FAU - Luiz, A C
AU  - Luiz AC
FAU - Camargo, L A
AU  - Camargo LA
FAU - Menani, J V
AU  - Menani JV
FAU - Renzi, A
AU  - Renzi A
FAU - Silveira, J E
AU  - Silveira JE
FAU - Paulino, M A
AU  - Paulino MA
FAU - Saad, W A
AU  - Saad WA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - L35JN3I7SJ (Ramipril)
SB  - IM
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/*pharmacology
MH  - Animals
MH  - Drinking Behavior/*drug effects/physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Ramipril/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Water Deprivation/*physiology
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
PST - ppublish
SO  - Braz J Med Biol Res. 1994 Dec;27(12):2909-13.