PMID- 7552276
OWN - NLM
STAT- MEDLINE
DCOM- 19951106
LR  - 20220223
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 681
IP  - 1-2
DP  - 1995 May 29
TI  - Inhibitory effects of dopamine and methylenedioxymethamphetamine (MDMA) on 
      glutamate-evoked firing of nucleus accumbens and caudate/putamen cells are 
      enhanced following cocaine self-administration.
PG  - 167-76
AB  - Rats were allowed to self-administer cocaine during a 3-h session for 15 days. 
      One to 11 days after the last cocaine exposure, rats were anesthetized with 
      urethane and effects of microiontophoretically-applied dopamine on 
      glutamate-evoked firing of neurons in the nucleus accumbens and in the 
      caudate/putamen were tested. Dopamine produced a dose-dependent inhibition of 
      glutamate-evoked firing in both the nucleus accumbens and the caudate/putamen of 
      rats that had been repeatedly exposed to self-administered cocaine and in control 
      rats. However, the DA-induced inhibition was significantly greater in the group 
      that had self-administered cocaine. The cocaine self-administration group was 
      significantly sensitized to the inhibitory effects of dopamine in both early (1-3 
      day) and later (9-11 days) periods of cocaine abstinence. Following cessation of 
      repeated cocaine self-administration sessions, nucleus accumbens cells were also 
      sensitized to the inhibitory effects of methylenedioxymethamphetamine (MDMA), a 
      drug that increases extracellular levels of DA and serotonin in the nucleus 
      accumbens. This sensitization to DA- and MDMA-induced inhibition in the nucleus 
      accumbens and in the striatum indicates that long-term neuroadaptations occur in 
      these regions of the nervous system following repeated exposure to 
      self-administered cocaine.
FAU - White, S R
AU  - White SR
AD  - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, 
      Washington State University, Pullman 99164, USA.
FAU - Harris, G C
AU  - Harris GC
FAU - Imel, K M
AU  - Imel KM
FAU - Wheaton, M J
AU  - Wheaton MJ
LA  - eng
GR  - DA08116/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain/cytology/drug effects/*physiology
MH  - Caudate Nucleus/cytology/drug effects/physiology
MH  - Cocaine/*pharmacology
MH  - Dopamine/*pharmacology
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Glutamic Acid/*pharmacology
MH  - Iontophoresis
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neurons/*drug effects
MH  - Nucleus Accumbens/cytology/drug effects/physiology
MH  - Putamen/cytology/drug effects/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
EDAT- 1995/05/29 00:00
MHDA- 1995/05/29 00:01
CRDT- 1995/05/29 00:00
PHST- 1995/05/29 00:00 [pubmed]
PHST- 1995/05/29 00:01 [medline]
PHST- 1995/05/29 00:00 [entrez]
AID - 0006-8993(95)00309-E [pii]
AID - 10.1016/0006-8993(95)00309-e [doi]
PST - ppublish
SO  - Brain Res. 1995 May 29;681(1-2):167-76. doi: 10.1016/0006-8993(95)00309-e.