PMID- 7553583
OWN - NLM
STAT- MEDLINE
DCOM- 19951108
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 83
IP  - 2
DP  - 1995 Sep
TI  - An eight-way variant t(15;17) in acute promyelocytic leukemia elucidated using 
      fluorescence in situ hybridization.
PG  - 136-9
AB  - A complex eight-way translocation was identified, with the aid of fluorescence in 
      situ hybridization (FISH), in a patient diagnosed as having acute promyelocytic 
      leukemia (APL). The balanced translocation was defined as 
      46,XY,t(1;6;7;6;17;15;12;3) (p22;q27;p15;q13;q21;q22;q13;p13), which includes a 
      der(15) chromosome consistent with the der(15) chromosome of the 
      t(15;17)(q22;q21) typically found in APL. The patient was treated with all-trans 
      retinoic acid (ATRA) and had a clinical course typical of the disease, which is 
      currently in remission after an autologous bone marrow transplant. The other 
      structural rearrangements appeared to have little effect on the biology of the 
      neoplasia.
FAU - Hiorns, L R
AU  - Hiorns LR
AD  - Academic Department of Haematology and Cytogenetics, Institute of Cancer 
      Research, Sutton, Surrey, UK.
FAU - Swansbury, G J
AU  - Swansbury GJ
FAU - Catovsky, D
AU  - Catovsky D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 15
MH  - *Chromosomes, Human, Pair 17
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/*genetics/therapy
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 016546089500048T [pii]
AID - 10.1016/0165-4608(95)00048-t [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1995 Sep;83(2):136-9. doi: 10.1016/0165-4608(95)00048-t.