PMID- 7554438
OWN - NLM
STAT- MEDLINE
DCOM- 19951114
LR  - 20191210
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 22
IP  - 5
DP  - 1995 May
TI  - Involvement of oxidative and L-arginine-NO pathways in the neurotoxicity of drugs 
      of abuse in vitro.
PG  - 381-2
AB  - 1. Inhibitors of nitric oxide (NO) formation or ADP-ribosylation attenuate 
      methamphetamine (METH)- and methylenedioxymetamphetamine (MDMA)-induced 
      neurotoxicity on dopaminergic and serotonergic cells in primary cultures. 2. They 
      also prevent METH-induced reactive gliosis in dopaminergic cultures. 3. 
      Overexpression of superoxide dismutase (SOD) in cells obtained from 
      SOD-transgenic mice also attenuates drug-induced toxicity. 4. These data indicate 
      a role for oxygen-based and NO free radicals in the mechanisms of cell death 
      associated with drugs of abuse in vitro.
FAU - Cerruti, C
AU  - Cerruti C
AD  - Molecular Neuropsychiatry Section, NIH/NIDA/Division of Intramural Research, 
      Baltimore, Maryland 21224, USA.
FAU - Sheng, P
AU  - Sheng P
FAU - Ladenheim, B
AU  - Ladenheim B
FAU - Epstein, C J
AU  - Epstein CJ
FAU - Cadet, J L
AU  - Cadet JL
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Dopamine Agents)
RN  - 0 (Free Radicals)
RN  - 0 (Illicit Drugs)
RN  - 0 (Serotonin Agents)
RN  - 20762-30-5 (Adenosine Diphosphate Ribose)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adenosine Diphosphate Ribose/antagonists & inhibitors/*metabolism
MH  - Animals
MH  - Arginine/*metabolism
MH  - Brain/cytology/drug effects/embryology
MH  - Cell Death/drug effects
MH  - Cells, Cultured
MH  - Dopamine/metabolism
MH  - Dopamine Agents/toxicity
MH  - Female
MH  - Free Radicals
MH  - Gene Expression Regulation/drug effects/genetics
MH  - Gliosis/prevention & control
MH  - Illicit Drugs/*toxicity
MH  - Methamphetamine/toxicity
MH  - Mice
MH  - Mice, Transgenic
MH  - N-Methyl-3,4-methylenedioxyamphetamine/toxicity
MH  - Nitric Oxide/antagonists & inhibitors/*metabolism
MH  - Oxidative Stress/*physiology
MH  - Pregnancy
MH  - Serotonin/metabolism
MH  - Serotonin Agents/toxicity
MH  - Superoxide Dismutase/genetics/metabolism
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1995.tb02025.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 1995 May;22(5):381-2. doi: 
      10.1111/j.1440-1681.1995.tb02025.x.