PMID- 7554499
OWN - NLM
STAT- MEDLINE
DCOM- 19951103
LR  - 20220318
IS  - 0192-253X (Print)
IS  - 0192-253X (Linking)
VI  - 17
IP  - 1
DP  - 1995
TI  - Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early 
      chick development.
PG  - 90-101
AB  - We report the cloning of fulllength cDNAs for a plasminogen-related growth 
      factor, hepatocyte growth factor/scatter factor (HGF/SF), its tyrosine kinase 
      receptor, c-met, and a close member of the same family, hepatocyte growth 
      factor-like/macrophage stimulating protein (HGF1/MSP), from the chick. We have 
      used these cDNAs to provide the first report of the expression of this family of 
      growth factors and the c-met receptor at early stages of vertebrate development. 
      RNAase protection and wholemount in situ hybridization were used on chick embryos 
      between formation of the primitive streak and early organogenesis. We find 
      patterns of expression for HGF/SF and its receptor c-met consistent with their 
      known roles in epithelial-mesenchymal transformation and angiogenesis. In 
      addition, these genes and HGF1/MSP are expressed in discrete locations within 
      developing somites, suggesting a role in paraxial mesodermal development. Very 
      strong and early expression of HGF/SF in the elevating limb buds suggests its 
      involvement in limb outgrowth. HGF1/MSP is expressed in the notochord and then in 
      the prospective floor plate region and could play a role in development of the 
      neural tube. Interestingly, c-met is often more closely associated with HGF1/MSP 
      than with its known ligand, HGF/SF, raising the possibility that c-met expression 
      may be induced by HGF1/MSP.
FAU - Thery, C
AU  - Thery C
AD  - Department of Genetics and Development, College of Physicians and Surgeons, 
      Columbia University, New York, New York 10032, USA.
FAU - Sharpe, M J
AU  - Sharpe MJ
FAU - Batley, S J
AU  - Batley SJ
FAU - Stern, C D
AU  - Stern CD
FAU - Gherardi, E
AU  - Gherardi E
LA  - eng
SI  - GENBANK/X84043
SI  - GENBANK/X84044
SI  - GENBANK/X84045
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Genet
JT  - Developmental genetics
JID - 7909963
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (Growth Substances)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (macrophage stimulating protein)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cell Adhesion
MH  - Cell Movement
MH  - Chick Embryo
MH  - Chickens/*genetics/*growth & development/physiology
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Gene Expression Regulation, Developmental
MH  - Growth Substances/*genetics/physiology
MH  - Hepatocyte Growth Factor/*genetics/physiology
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Neovascularization, Physiologic
MH  - *Proto-Oncogene Proteins
MH  - Proto-Oncogene Proteins c-met
MH  - Receptor Protein-Tyrosine Kinases/*genetics/physiology
MH  - Sequence Homology, Amino Acid
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1002/dvg.1020170110 [doi]
PST - ppublish
SO  - Dev Genet. 1995;17(1):90-101. doi: 10.1002/dvg.1020170110.