PMID- 7554934
OWN - NLM
STAT- MEDLINE
DCOM- 19951106
LR  - 20190920
IS  - 0300-8207 (Print)
IS  - 0300-8207 (Linking)
VI  - 32
IP  - 1-4
DP  - 1995
TI  - Analysis of tooth development in mice bearing a TGF-beta 1 null mutation.
PG  - 41-6
AB  - While transforming growth factor-beta 1 (TGF-beta 1) and its related mammalian 
      isoforms TGF-beta 2 and TGF-beta 3 are coexpressed in developing tooth organs, 
      the specific biological role of each isoform is unknown. To delineate the role of 
      TGF-beta 1 in odontogenesis, we have studied tissues from mice that lack a 
      functional TGF-beta 1 gene. Histologic analyses revealed that in TGF-beta 1 (-/-) 
      mice, tooth morphogenesis, cytodifferentiation and histogenesis were unaffected. 
      Using in situ hybridization we studied the patterns of distribution of TGFs-beta 
      1, beta 2 and beta 3 in the TGF-beta 1 (+/+, +/- and -/-) genotypes. Our results 
      indicate no detectable TGF-beta 1 mRNA in null tissues while TGFs-beta 2 and beta 
      3 showed normal temporal-spatial patterns of distribution. Using antibodies 
      against TGF-beta 1, we observed immunoreactive TGF-beta 1 in tissues from null 
      mice suggesting that maternally-derived TGF-beta 1 may be involved in the rescue 
      of several developmental events in TGF-beta 1 knockout mice.
FAU - D'Souza, R N
AU  - D'Souza RN
AD  - University of Texas-Houston Health Science Center, Dental Branch 77030, USA.
FAU - Litz, M
AU  - Litz M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Connect Tissue Res
JT  - Connective tissue research
JID - 0365263
RN  - 0 (Antibodies)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Antibodies
MH  - Cell Differentiation/genetics
MH  - Dental Papilla/cytology/metabolism
MH  - Enamel Organ/cytology/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Genotype
MH  - Heterozygote
MH  - Homozygote
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Knockout
MH  - Morphogenesis/genetics
MH  - Mutation/*genetics
MH  - Odontogenesis/*genetics
MH  - RNA, Messenger/genetics
MH  - Tooth Germ/cytology/metabolism
MH  - Transforming Growth Factor beta/*genetics
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.3109/03008209509013704 [doi]
PST - ppublish
SO  - Connect Tissue Res. 1995;32(1-4):41-6. doi: 10.3109/03008209509013704.