PMID- 7556962
OWN - NLM
STAT- MEDLINE
DCOM- 19951024
LR  - 20220309
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 44
IP  - 10
DP  - 1995 Oct
TI  - Differential immunogenetic determinants of polyclonal insulin autoimmune syndrome 
      (Hirata's disease) and monoclonal insulin autoimmune syndrome.
PG  - 1227-32
AB  - The insulin autoimmune syndrome (IAS), or Hirata's disease, is characterized by 
      the combination of fasting hypoglycemia, high concentration of total serum 
      immunoreactive insulin, and presence of autoantibodies to native human insulin in 
      serum. Autoantibody production is classified as monoclonal or polyclonal, with 
      the majority of IAS cases classified as polyclonal. Previously, we observed a 
      striking association between the human leukocyte antigen (HLA) class II alleles 
      DRB1*0406/DQA1* 0301/DQB1*0302 and Japanese IAS patients with polyclonal insulin 
      autoantibodies (IAAs) and T-cell recognition of human insulin in the context of 
      DRB1*0406 molecules. Because of such a strong HLA association in IAS, we 
      performed intra- and interethnic studies on IAS-associated DRB1 alleles and 
      searched for the critical amino acid residue(s) for IAS pathogenesis. Glutamate 
      at position 74 in the HLA-DR4 beta 1-chain was presumed to be essential to the 
      production of polyclonal IAA in IAS, whereas alanine at the same position of the 
      HLA-DR beta 1-chain might be important in the production of monoclonal IAA.
FAU - Uchigata, Y
AU  - Uchigata Y
AD  - Diabetes Center, Tokyo Women's Medical College, Japan.
FAU - Tokunaga, K
AU  - Tokunaga K
FAU - Nepom, G
AU  - Nepom G
FAU - Bannai, M
AU  - Bannai M
FAU - Kuwata, S
AU  - Kuwata S
FAU - Dozio, N
AU  - Dozio N
FAU - Benson, E A
AU  - Benson EA
FAU - Ronningen, K S
AU  - Ronningen KS
FAU - Spinas, G A
AU  - Spinas GA
FAU - Tadokoro, K
AU  - Tadokoro K
AU  - et al.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Insulin)
RN  - 0 (Insulin Antibodies)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Autoimmune Diseases/*genetics/*immunology
MH  - Fasting
MH  - Female
MH  - *Genes, MHC Class II
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Hypoglycemia
MH  - Insulin/*blood
MH  - Insulin Antibodies/*blood
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Syndrome
MH  - T-Lymphocytes/immunology
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.2337/diab.44.10.1227 [doi]
PST - ppublish
SO  - Diabetes. 1995 Oct;44(10):1227-32. doi: 10.2337/diab.44.10.1227.