PMID- 7561385
OWN - NLM
STAT- MEDLINE
DCOM- 19951122
LR  - 20190909
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 68
IP  - 3
DP  - 1995 Sep
TI  - Chromosome painting in highly irradiated Chernobyl victims: a follow-up study to 
      evaluate the stability of symmetrical translocations and the influence of clonal 
      aberrations for retrospective dose estimation.
PG  - 257-62
AB  - Follow-up fluorescence in situ hybridization (FISH) measurements of symmetrical 
      translocations were performed in peripheral blood lymphocytes from 12 highly 
      irradiated victims of the Chernobyl nuclear power plant accident biannually, 
      between September 1991 and July 1994, to investigate the persistence of these 
      aberration type with time post-exposure. Translocations were determined using 
      biotin-labelled painting DNA probes for human chromosomes 1, 4 and 12 and a 
      digoxigenin-labelled alpha-satellite pancentromeric DNA probe. In 11 of 12 cases 
      the translocation frequencies remained fairly constant during the observation 
      period, which allows to generate comparable dose estimates on the various 
      sampling times. In one case (no. 9) the existence of a cell clone containing the 
      consistent chromosome rearrangement t(1;13) (q25;q14) was identified using FISH 
      in rehybridized slides with a digoxigenin-labelled painting DNA probe for 
      chromosome 13 and a separate G-banding analysis. To obtain reliable dose 
      estimates, total translocation frequency has to be corrected for the high 
      contribution (16.5-23.5%) of this clonal translocation.
FAU - Salassidis, K
AU  - Salassidis K
AD  - Institut fur Strahlenbiologie, GSF-Forschungszentrum fur Umwelt und Gesundheit 
      Neuherberg, Oberschleissheim, Germany.
FAU - Georgiadou-Schumacher, V
AU  - Georgiadou-Schumacher V
FAU - Braselmann, H
AU  - Braselmann H
FAU - Muller, P
AU  - Muller P
FAU - Peter, R U
AU  - Peter RU
FAU - Bauchinger, M
AU  - Bauchinger M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (Radioactive Pollutants)
SB  - IM
MH  - Accidents
MH  - *Chromosome Aberrations
MH  - Chromosomes/*radiation effects
MH  - Clone Cells
MH  - Dose-Response Relationship, Radiation
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Power Plants
MH  - Radioactive Pollutants/*toxicity
MH  - Time Factors
MH  - Translocation, Genetic
MH  - Ukraine
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - QGF1BNTJL5VH97D0 [pii]
AID - 10.1080/09553009514551181 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 1995 Sep;68(3):257-62. doi: 10.1080/09553009514551181.