PMID- 7563136
OWN - NLM
STAT- MEDLINE
DCOM- 19951103
LR  - 20190904
IS  - 0022-2844 (Print)
IS  - 0022-2844 (Linking)
VI  - 41
IP  - 4
DP  - 1995 Oct
TI  - Presence and abundance of CENP-B box sequences in great ape subsets of 
      primate-specific alpha-satellite DNA.
PG  - 487-91
AB  - CENP-B, a highly conserved centromere-associated protein, binds to 
      alpha-satellite DNA, the centromeric satellite of primate chromosomes, at a 17-bp 
      sequence, the CENP-B box. By fluorescence in situ hybridization (FISH) with an 
      oligomer specific for the CENP-B box sequence, we have demonstrated the abundance 
      of CENP-B boxes on all chromosomes (except the Y) of humans, chimpanzee, pygmy 
      chimpanzee, gorilla, and orangutan. This sequence motif was not detected in the 
      genomes of other primates, including gibbons, Old and New World monkeys, and 
      prosimians. Our results indicate that the CENP-B box containing subtype of 
      alpha-satellite DNA may have emerged recently in the evolution of the 
      large-bodied hominoids, after divergence of the phylogenetic lines leading to 
      gibbons and apes; the box is thus on the order of 15-25 million years of age. The 
      rapid process of dispersal and fixation of the CENP-B box sequence throughout the 
      human and great ape genomes is thought to be a consequence of concerted evolution 
      of alpha-satellite subsets on both homologous and nonhomologous chromosomes.
FAU - Haaf, T
AU  - Haaf T
AD  - Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, 
      USA.
FAU - Mater, A G
AU  - Mater AG
FAU - Wienberg, J
AU  - Wienberg J
FAU - Ward, D C
AU  - Ward DC
LA  - eng
GR  - HG-00246/HG/NHGRI NIH HHS/United States
GR  - HG-00272/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - J Mol Evol
JT  - Journal of molecular evolution
JID - 0360051
RN  - 0 (Autoantigens)
RN  - 0 (CENPB protein, human)
RN  - 0 (Centromere Protein B)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (DNA, Satellite)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Animals
MH  - *Autoantigens
MH  - Base Sequence
MH  - Binding Sites
MH  - *Biological Evolution
MH  - Centromere Protein B
MH  - Chromosomal Proteins, Non-Histone/*metabolism
MH  - Chromosome Mapping
MH  - DNA, Satellite/*chemistry/genetics/*metabolism
MH  - DNA-Binding Proteins/metabolism
MH  - Gorilla gorilla/genetics
MH  - Hominidae/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Molecular Sequence Data
MH  - Oligonucleotide Probes
MH  - Pan troglodytes/genetics
MH  - Pongo pygmaeus/genetics
MH  - Primates/*genetics
MH  - Y Chromosome
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
AID - 10.1007/BF00160320 [doi]
PST - ppublish
SO  - J Mol Evol. 1995 Oct;41(4):487-91. doi: 10.1007/BF00160320.