PMID- 7564103
OWN - NLM
STAT- MEDLINE
DCOM- 19951114
LR  - 20190725
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 48
IP  - 2
DP  - 1995 Aug
TI  - Human mesangial cell production of monocyte chemoattractant protein-1: modulation 
      by lovastatin.
PG  - 363-71
AB  - Macrophages play a critical role in the progression of clinical and experimental 
      glomerular injury. Serum-stimulated human fetal mesangial cells in culture 
      produce a chemotactic factor that is monocyte-selective. This chemotactic factor 
      is most likely monocyte chemoattractant protein-1 (MCP-1) as a monoclonal 
      antibody directed against MCP-1, but not an irrelevant antibody, suppressed the 
      mesangial cell-derived chemotactic activity. Inhibition of 
      3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by lovastatin resulted 
      in a reduction of the mesangial cell-derived chemotactic activity as well as 
      MCP-1 mRNA expression. The inhibitory effects of lovastatin in the presence of 
      exogenous cholesterol were reversed by mevalonate, suggesting a role for 
      isoprenoid intermediates of the mevalonate pathway and/or isoprenylated proteins 
      in mesangial cell MCP-1 regulation. These findings suggest an additional 
      mechanism by which HMG-CoA reductase inhibition in vivo may reduce glomerular 
      injury.
FAU - Kim, S Y
AU  - Kim SY
AD  - Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota, 
      USA.
FAU - Guijarro, C
AU  - Guijarro C
FAU - O'Donnell, M P
AU  - O'Donnell MP
FAU - Kasiske, B L
AU  - Kasiske BL
FAU - Kim, Y
AU  - Kim Y
FAU - Keane, W F
AU  - Keane WF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Chemokine CCL2)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - 9LHU78OQFD (Lovastatin)
SB  - IM
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Glomerular Mesangium/cytology/*metabolism
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors
MH  - Lovastatin/*pharmacology
MH  - RNA, Messenger/antagonists & inhibitors/metabolism
MH  - Time Factors
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - S0085-2538(15)59076-5 [pii]
AID - 10.1038/ki.1995.304 [doi]
PST - ppublish
SO  - Kidney Int. 1995 Aug;48(2):363-71. doi: 10.1038/ki.1995.304.