PMID- 7564153
OWN - NLM
STAT- MEDLINE
DCOM- 19951120
LR  - 20071115
IS  - 0300-8630 (Print)
IS  - 0300-8630 (Linking)
VI  - 207
IP  - 4
DP  - 1995 Jul-Aug
TI  - [Long-term infusion of L-asparaginase--an alternative to intramuscular 
      injection?].
PG  - 207-10
AB  - Nine children of the ALL-REZ BFM 87 and 90 trial received L-Asparginase (L-ASP) 
      as a continuous infusion for 48-72 hs (i.e. 25 therapy cycles). Seven patients 
      had had an allergic reaction towards an i.m. application (i.m., 29 therapy 
      cycles). Two further patients got L-ASP initially as continuous infusion. The 
      i.m. applications were carried out 19 times with Erwinia and 10 times with E. 
      coli-Asparaginase, the continuous infusions 15 times with Erwinia and 10 times 
      with E. coli-Asparaginase. In case of four patients continuous infusions of the 
      same L-ASP type (E. coli or Erwinia) was well tolerated, after there had been an 
      allergic reaction after i.m. application. Allergic reactions after i.m. 
      application occurred during 10 courses as local painful erythema, during five 
      courses as urticaria, during four courses as a general exanthema during one 
      course as difficult breathing and during a further course as drop in blood 
      pressure. After continuous infusion of L-ASP urticaria and difficult breathing 
      occurred once and a transient exanthema two times. There was no anaphylactic 
      reaction in any case. These data show that i.m. application of L-ASP causes no 
      life-threatening side effects but allergic reactions (local pain and swelling) 
      which clearly impaired general condition. Continuous infusion is a 
      pharmacologically equivalent alternative with less impairment of the patients' 
      general condition.
FAU - Rodriguez, T
AU  - Rodriguez T
AD  - Universitatsklinikum Rudolf Virchow, Standort Wedding, Kinderklinik u. 
      Poliklinik, Hamatologie/Onkologie, Berlin.
FAU - Baumgarten, E
AU  - Baumgarten E
FAU - Fengler, R
AU  - Fengler R
FAU - Soumpasis, D
AU  - Soumpasis D
FAU - Henze, G
AU  - Henze G
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Langzeitinfusion von L-Asparaginase--eine Alternative zur intramuskularen 
      Injektion?
PL  - Germany
TA  - Klin Padiatr
JT  - Klinische Padiatrie
JID - 0326144
RN  - 0 (Antineoplastic Agents)
RN  - EC 3.5.1.1 (Asparaginase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antineoplastic Agents/*administration & dosage/adverse effects
MH  - Asparaginase/*administration & dosage/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Drug Eruptions/etiology/prevention & control
MH  - Drug Hypersensitivity/etiology/prevention & control
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Injections, Intramuscular
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
MH  - Retrospective Studies
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1055/s-2008-1046540 [doi]
PST - ppublish
SO  - Klin Padiatr. 1995 Jul-Aug;207(4):207-10. doi: 10.1055/s-2008-1046540.