PMID- 7564162
OWN - NLM
STAT- MEDLINE
DCOM- 19951109
LR  - 20190920
IS  - 0023-5679 (Print)
IS  - 0023-5679 (Linking)
VI  - 42
IP  - 2
DP  - 1995
TI  - Chlamydia pneumoniae infection in children with lower respiratory tract 
      infections.
PG  - 107-20
AB  - The incidence of antibody and the clinical features of Chlamydia pneumoniae 
      (C.pneumoniae) infection have not been studied in children in Japan. We 
      investigated the incidence of C.pneumoniae antibody in sera from 580 healthy 
      children (including 30 umbilical cord blood samples) during the 2-year period 
      between June 1992 and June 1994. The antibody titer was determined by a 
      microimmunofluorescence (MIF) test by using the elementary body of C.pneumoniae 
      TW-183 as the antigen. Umbilical cord blood samples were positive for the 
      antibody in 50% of newborns tested at birth. The incidence of positivity 
      decreased to 0% in 1-year-old children. It was still low in children up to 5 
      years of age and then increased rapidly in children 6 years of age or older. The 
      positivity reached increased rapidly in children 6 years of age or older. The 
      positivity reached 55% in 7-year-old children and remained at this level in 
      children older than 7 years of age. High antibody titer (IgG > or = 512), 
      indicating recent infection, was observed in 13 (2.2%) of the 580 children, two 
      of whom showed no symptoms. We detected the pathogen in throat swabs by culture 
      and capillary polymerase chain reaction (PCR), and determined IgM and IgG serum 
      titers to C.pneumoniae in 130 children with lower respiratory tract infection (91 
      with pneumonia and 39 with bronchitis) between December 1993 and December 1994. 
      The infection due to C.pneumoniae was confirmed in 10 (7.7%). Of these, 7 were 
      boys and 3 were girls, ranging in age from 9 months to 12 years. The clinical 
      manifestations of the infection were mild symptoms like in common cold; 
      post-nasal discharge, hoarseness and prolonged cough were relatively 
      characteristic. There was no significant difference in the incidence of serum 
      positivity between the healthy children group and the patients group. The present 
      study suggests that primary-schoolers show antibodies for C.pneumoniae with 
      nearly the same frequency as adults. Mild clinical symptoms are very common in 
      C.pneumoniae infections in children as in adults.
FAU - Yamada, S
AU  - Yamada S
AD  - Department of Pediatrics and Child Health, Kurume University School of Medicine, 
      Japan.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Kurume Med J
JT  - The Kurume medical journal
JID - 2985210R
SB  - IM
MH  - Adolescent
MH  - Bronchitis/*epidemiology/microbiology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Chlamydia Infections/*epidemiology
MH  - Chlamydophila pneumoniae/*isolation & purification
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Male
MH  - Pneumonia, Bacterial/*epidemiology/microbiology
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.2739/kurumemedj.42.107 [doi]
PST - ppublish
SO  - Kurume Med J. 1995;42(2):107-20. doi: 10.2739/kurumemedj.42.107.