PMID- 7565497
OWN - NLM
STAT- MEDLINE
DCOM- 19951122
LR  - 20190920
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 17
IP  - 4
DP  - 1995 Jul-Aug
TI  - Effects of prenatal cocaine exposure on haloperidol-induced increases in 
      prolactin release and dopamine turnover in weanling, periadolescent, and adult 
      offspring.
PG  - 507-14
AB  - Offspring of dams given 40 mg/kg cocaine SC on gestational days (GD) 8-20 (E8-20) 
      (C40), dams given 0.9% saline SC on E8-20 that were pair fed and watered to C40 
      dams (PF), and untreated control dams given ad lib access to food and water (LC) 
      were challenged with haloperidol (0.0, 0.05, 0.10, or 0.50 mg/kg) at either 21, 
      35, or 60 days postnatally (P21, 35, 60). One hour postinjection, animals were 
      sacrificed, trunk blood collected for assay of prolactin, and the striatum (ST) 
      and nucleus accumbens (NAc) removed. The ratio of the dopamine metabolites 
      3,4-dihydroxyphenylacetic acid and homovanillic acid to dopamine (DA) as well as 
      the ratio of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) to 
      serotonin (5-HT) were determined in these brain regions as an index of DA and 
      5-HT turnover, respectively. Assessment of 5-HIAA/5-HT ratios did not indicate 
      any reliable dose or prenatal treatment effects. Reminiscent of previous findings 
      obtained in C40 offspring at P11 (35), P21 C40 offspring exhibited a slightly 
      reduced sensitivity to haloperidol relative to LC controls both in terms of DA 
      ratios in the NAc as well as plasma prolactin levels. These findings were also 
      evident in PF controls suggesting that they may be the result of prenatal 
      undernutrition. Furthermore, this reduced sensitivity was not evident at the 
      older test ages. At P60, planned comparisons revealed haloperidol-induced 
      increases in prolactin levels in C40 males but not PF or LC males; these findings 
      could potentially reflect feminization in males following prenatal cocaine 
      exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Goodwin, G A
AU  - Goodwin GA
AD  - Department of Psychology, Binghamton University, NY 13902-6000, USA.
FAU - Rajachandran, L
AU  - Rajachandran L
FAU - Moody, C A
AU  - Moody CA
FAU - Francis, R
AU  - Francis R
FAU - Kuhn, C M
AU  - Kuhn CM
FAU - Spear, L P
AU  - Spear LP
LA  - eng
GR  - K02 DA00140/DA/NIDA NIH HHS/United States
GR  - R01 DA14478/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Dopamine Antagonists)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 9002-62-4 (Prolactin)
RN  - I5Y540LHVR (Cocaine)
RN  - J6292F8L3D (Haloperidol)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Aging/metabolism
MH  - Analysis of Variance
MH  - Animals
MH  - Cocaine/*pharmacology
MH  - Corpus Striatum/metabolism
MH  - Dopamine/*metabolism
MH  - Dopamine Antagonists/*pharmacology
MH  - Female
MH  - Haloperidol/*pharmacology
MH  - Homovanillic Acid/metabolism
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Prolactin/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 0892-0362(95)00010-O [pii]
AID - 10.1016/0892-0362(95)00010-o [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1995 Jul-Aug;17(4):507-14. doi: 
      10.1016/0892-0362(95)00010-o.