PMID- 7565671
OWN - NLM
STAT- MEDLINE
DCOM- 19951025
LR  - 20210526
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 15
IP  - 10
DP  - 1995 Oct
TI  - New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially 
      modulate transcription and do not bind 9-cis retinoic acid.
PG  - 5226-34
AB  - Retinoid X receptors (RXRs), along with retinoic acid (RA) receptors (RARs), 
      mediate the effects of RA on gene expression. Three subtypes of RXRs (alpha, 
      beta, and gamma) which bind to and are activated by the 9-cis stereoisomer of RA 
      have been characterized. They activate gene transcription by binding to specific 
      sites on DNA as homodimers or as heterodimers with RARs and other related nuclear 
      receptors, including the vitamin D receptor, thyroid hormone receptors (TRs), and 
      peroxisome proliferator-activated receptors. Two additional RXR subtypes (delta 
      and epsilon) isolated from zebra fish cDNA libraries are described here; although 
      both subtypes form DNA-binding heterodimers with RARs and TR, neither binds 9-cis 
      RA, and both are transcriptionally inactive on RXR response elements. In 
      cotransfection studies with TR, the delta subtype was found to function in a 
      dominant negative manner, while the epsilon subtype had a slight stimulatory 
      effect on thyroid hormone (T3)-dependent transcriptional activity. The discovery 
      of these two novel receptors in zebra fish expands the functional repertoire of 
      RXRs to include ligand-independent and dominant negative modulation of type II 
      receptor function.
FAU - Jones, B B
AU  - Jones BB
AD  - Department of Biochemistry, Queen's University, Kingston, Ontario, Canada.
FAU - Ohno, C K
AU  - Ohno CK
FAU - Allenby, G
AU  - Allenby G
FAU - Boffa, M B
AU  - Boffa MB
FAU - Levin, A A
AU  - Levin AA
FAU - Grippo, J F
AU  - Grippo JF
FAU - Petkovich, M
AU  - Petkovich M
LA  - eng
SI  - GENBANK/U29894
SI  - GENBANK/U29940
SI  - GENBANK/U29941
SI  - GENBANK/U29942
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Ligands)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 5688UTC01R (Tretinoin)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA/metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - Genes/genetics
MH  - Kinetics
MH  - Ligands
MH  - Molecular Sequence Data
MH  - RNA, Messenger/biosynthesis
MH  - Receptors, Retinoic Acid/genetics/*metabolism/physiology
MH  - Receptors, Thyroid Hormone/metabolism
MH  - Retinoid X Receptors
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/genetics/*metabolism/physiology
MH  - Transcriptional Activation/*physiology
MH  - Tretinoin/*metabolism
MH  - Triiodothyronine/physiology
MH  - Zebrafish/embryology/*genetics
PMC - PMC230770
EDAT- 1995/10/01 00:00
MHDA- 1995/10/01 00:01
PMCR- 1995/10/01
CRDT- 1995/10/01 00:00
PHST- 1995/10/01 00:00 [pubmed]
PHST- 1995/10/01 00:01 [medline]
PHST- 1995/10/01 00:00 [entrez]
PHST- 1995/10/01 00:00 [pmc-release]
AID - 10.1128/MCB.15.10.5226 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1995 Oct;15(10):5226-34. doi: 10.1128/MCB.15.10.5226.