PMID- 7568444
OWN - NLM
STAT- MEDLINE
DCOM- 19951103
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 58
IP  - 2
DP  - 1995 Aug
TI  - Failure of intrabulbar and peripheral administration of N omega-nitro-L-arginine 
      to prevent the formation of an olfactory memory in mice.
PG  - 387-91
AB  - The gaseous neurotransmitter molecule nitric oxide (NO) has recently generated a 
      lot of interest on account of its possible physiological role in several models 
      of learning and memory, both in vitro and in vivo. The presence of its 
      synthesizing enzyme has been reported in the granule cell and external plexiform 
      layers of the accessory olfactory bulb (AOB) in mice and rats. We have tested the 
      effect of different doses of the nitric oxide synthase inhibitor, N 
      omega-nitro-L-arginine applied locally and peripherally, on the formation of 
      olfactory recognition memory in the context of pregnancy block in mice. Local 
      infusions of 5, 10, and 40 nmol of the NOS inhibitor into the AOB failed to 
      prevent memory formation of the stud male without affecting the effectiveness of 
      the strange male to induce pregnancy block. Peripheral administration of the NOS 
      inhibitor produced a pregnancy block rate that was linearly related to the dose 
      regardless of whether or not exposure to the familiar or no male subsequently 
      followed. This suggests that the effect of peripheral administration of the NOS 
      inhibitor on memory formation could not be assessed using this experimental 
      paradigm. The observations made in this study do not enable us to envisage any 
      critical or primary physiological role for NO in this memory model. Its role, at 
      best, may be modulatory and not obligatory.
FAU - Okere, C O
AU  - Okere CO
AD  - Department of Physiology, Kochi Medical School, Japan.
FAU - Kaba, H
AU  - Kaba H
FAU - Higuchi, T
AU  - Higuchi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Enzyme Inhibitors)
RN  - 2149-70-4 (Nitroarginine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
SB  - IM
MH  - Animals
MH  - Arginine/administration & dosage/*analogs & derivatives/pharmacology
MH  - Cognition/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/*pharmacology
MH  - Estrus/physiology
MH  - Female
MH  - Injections
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Memory/*drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nitric Oxide/*antagonists & inhibitors
MH  - Nitric Oxide Synthase/*antagonists & inhibitors
MH  - Nitroarginine
MH  - Olfactory Bulb/*physiology
MH  - Pregnancy
MH  - Smell/*drug effects
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 0031-9384(95)00074-S [pii]
AID - 10.1016/0031-9384(95)00074-s [doi]
PST - ppublish
SO  - Physiol Behav. 1995 Aug;58(2):387-91. doi: 10.1016/0031-9384(95)00074-s.