PMID- 7569410
OWN - NLM
STAT- MEDLINE
DCOM- 19951121
LR  - 20071114
IS  - 0270-9295 (Print)
IS  - 0270-9295 (Linking)
VI  - 15
IP  - 4
DP  - 1995 Jul
TI  - Origin of the glomerular vasculature in the developing kidney.
PG  - 300-14
AB  - Mechanisms regulating the establishment of the glomerular endothelium and 
      mesangium during glomerulogenesis are not understood. In this article, we discuss 
      two different blood vessel growth processes: vasculogenesis and angiogenesis, 
      with particular attention on how these processes might operate in the developing 
      kidney. Results from metanephric organ cultures and interspecies grafts are also 
      interpreted with an emphasis on generation of the renal microvasculature. Among 
      the several growth factors identified in the metanephros, many (eg, fibroblast 
      growth factor [FGF], vascular endothelial growth factor [VEGF], platelet-derived 
      growth factor [PDGF], epidermal growth factor/transforming growth factor-alpha 
      [EGF/TGF-alpha], hepatocyte growth factor/scatter factor [HGF/SF], and 
      insulinlike growth factor [IGF]) have angiogenic properties, and these are 
      discussed in relation to formation of the glomerulus. How extracellular matrices 
      and proteases might be involved in vascularization are also considered.
FAU - Hyink, D P
AU  - Hyink DP
AD  - Department of Cell Biology, University of Alabama at Birmingham 35294-0019, USA.
FAU - Abrahamson, D R
AU  - Abrahamson DR
LA  - eng
GR  - DK34972/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Semin Nephrol
JT  - Seminars in nephrology
JID - 8110298
RN  - 0 (Growth Substances)
SB  - IM
MH  - Animals
MH  - Endothelium, Vascular/*embryology/ultrastructure
MH  - Growth Substances/physiology
MH  - Kidney Glomerulus/*blood supply/embryology/ultrastructure
MH  - Organ Culture Techniques
RF  - 140
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
PST - ppublish
SO  - Semin Nephrol. 1995 Jul;15(4):300-14.